Dynamics of ERK signaling pathways during L-LTP induction(Miningou et al 2021)

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Accession:267073
Biochemical model of five signaling pathways (3 activated by cAMP and 2 activated by calcium) leading to ERK activation during L-LTP induction. Simulations show that calcium and cAMP work synergistically to activate ERK and that stimuli given with large inter-trial intervals activate more ERK than shorter intervals. Epac and RasGRF pathways contribute to early dynamics and PKA and CaMKII contribute to late dynamics of ERK activation.
Reference:
1 . Miningou NT, Jedrzejewska-Szmek J, Blackwell KT (2021) Temporal pattern and synergy influence activity of ERK signaling pathways during L-LTP induction Elife [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Molecular Network;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s):
Gap Junctions:
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Simulation Environment: NeuroRD;
Model Concept(s): Long-term Synaptic Plasticity; Stochastic simulation; Reaction-diffusion;
Implementer(s): Blackwell, Avrama [avrama at gmu.edu]; Jedrzejewska-Szmek, Joanna ;
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell;
 
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