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Dynamics of ERK signaling pathways during L-LTP induction(Miningou et al 2021)
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Biochemical model of five signaling pathways (3 activated by cAMP and 2 activated by calcium) leading to ERK activation during L-LTP induction. Simulations show that calcium and cAMP work synergistically to activate ERK and that stimuli given with large inter-trial intervals activate more ERK than shorter intervals. Epac and RasGRF pathways contribute to early dynamics and PKA and CaMKII contribute to late dynamics of ERK activation.
Miningou NT, Jedrzejewska-Szmek J, Blackwell KT (2021) Temporal pattern and synergy influence activity of ERK signaling pathways during L-LTP induction
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Hippocampus CA1 pyramidal GLU cell;
Long-term Synaptic Plasticity;
Blackwell, Avrama [avrama at gmu.edu];
Jedrzejewska-Szmek, Joanna ;
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Hippocampus CA1 pyramidal GLU cell
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