Spatial constrains of GABAergic rheobase shift (Lombardi et al., accepted)

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Accession:267142
In this models we investigated how the threshold eGABA, at which GABAergic inhibition switches to excitation, depends on the spatiotemporal constrains in a ball-and-stick neurons and a neurons with a topology derived from an reconstructed neuron.
Reference:
1 . Lombardi A, Luhmann HJ, Kilb W (accepted) Modelling the spatial and temporal constrains of the GABAergic influence on neuronal excitability PLoS Computational Biology
Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA3 pyramidal GLU cell;
Channel(s):
Gap Junctions:
Receptor(s): AMPA; GabaA;
Gene(s):
Transmitter(s): Glutamate; Gaba;
Simulation Environment: NEURON;
Model Concept(s): Development; Action Potentials;
Implementer(s): Kilb, Werner [wkilb at uni-mainz.de];
Search NeuronDB for information about:  Hippocampus CA3 pyramidal GLU cell; GabaA; AMPA; Gaba; Glutamate;
// ExciThresh__Detection_div-Erev_dif-gGABA_1_1.hoc
// Simulation to determine the excitation theshold for synaptic GABAergic inputs
// Variabel g_GABA up to XX nS to check when AP are evoked
// 
// Author: Werner Kilb
// Version 1.1
// Date: 26-Jan-2021
//--------------------------------------------------
strdef VERSION
VERSION = "1.1"
printf("ExciThresh_Detection_Mrk-AP-Ball_div-Erev_dif-gGABA, Version %s \n", VERSION)

// 1. Parameters to adjust for simulation of sweep -------------------------------------------

    // ------- 1.1 GABAergic Parameters (tonic) ----------------------------------------------------------
    GABA_Rise = 0.5         // ms arbitraray Value
    GABA_Decay = 37         // ms from Lombardi et a. (2018)
    GABA_Time = 10
    GABA_Rev = -43.090
    gGABA = 0.928



// 2. Define Variables and outputs ---------------------------------------------------------------

    // ----- 2.1 Runtime Variables --------------------------------------------------------------------------
    tstop = 1000          // Duration
    v_init = -50.5       // Initial voltage
    dt = 0.1            // Step Interval in ms
    steps_per_ms = 1     // Plot 5 points per ms
    celsius = 31         // measured at°C

    // --- 2.2 Initialize Synapses ----------------------------------------------------------------------
       // Definition of synapse objects
       objref GABA_Syn_Soma  

    // distribute synapses  -----------------------------------------------------------
       soma {
         GABA_Syn_Soma = new Exp2Syn(0.5)
         GABA_Syn_Soma.tau1 = GABA_Rise
         GABA_Syn_Soma.tau2 = GABA_Decay
         GABA_Syn_Soma.e = GABA_Rev
       }
                                             

    // generate and link netstim object -----------------------------------------------
      objref GABA_Stim                             //generate Netstim object for synaptic stimulation
         GABA_Stim = new NetStim(0.5)
         GABA_Stim.number = 1
         GABA_Stim.start = GABA_Time
         GABA_Stim.noise = 0


      objref Net_GABA_Syn_Soma   //Generate Netcon objects to connect Stim with the synapse   
         soma{ 
            Net_GABA_Syn_Soma = new NetCon(GABA_Stim, GABA_Syn_Soma, 0, 0, gGABA)
          }


// Run Program ----------------------------------------------

run()

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