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Spreading Depolarization in Brain Slices (Kelley et al. 2022)

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Accession:267259
A tissue-scale model of spreading depolarization (SD) in brain slices. We used the NEURON simulator's reaction-diffusion framework to implement embed thousands of neurons (based on the the model from Wei et al. 2014) in the extracellular space of a brain slice, which is itself embedded in an bath solution. We initiate SD in the slice by elevating extracellular K+ in a spherical region at the center of the slice. Effects of hypoxia and propionate on the slice were modeled by appropriate changes to the volume fraction and tortuosity of the extracellular space and oxygen/chloride concentrations.
Reference:
1 . Kelley C, Newton AJH, Hrabetova S, McDougal RA, Lytton WW (2022) Multiscale Computer Modeling of Spreading Depolarization in Brain Slices eNeuro [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Extracellular; Neuron or other electrically excitable cell; Glia;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): Na/K pump; NKCC1; KCC2; I Na, leak; I Cl, leak; I K,leak; I K; I Na,t;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Spreading depolarization; Spreading depression; Reaction-diffusion;
Implementer(s): Kelley, Craig; Newton, Adam J H [adam.newton at yale.edu]; Lytton, William [bill.lytton at downstate.edu]; McDougal, Robert [robert.mcdougal at yale.edu];
Search NeuronDB for information about:  I Na,t; I K; I K,leak; Na/K pump; I Cl, leak; I Na, leak; KCC2; NKCC1;
 
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SDinSlice-main
cfgs
small_hypoxic_sim.json
small_sim.json
                            
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