Hyperpolarization-activated inward current and dynamic range of electrical synapse (Stein et al '22)

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Accession:267286
Electrical synaptic transmission and voltage-gated ionic currents are often studied independently from one another. This model allows to study the interactions between the hyperpolarization-activated inward ionic current and a rectifying electrical synapse. Two single compartment nonspiking neurons are coupled through a rectifying electrical synapse. Current pulses are applied into the presynaptic neuron. The amplitude of the electrical postsynaptic potentials is measured. Ih can be added to either the pre- or postsynaptic neuron, or both. The cells represent the the MCN1 and LG neurons in the crab stomatogastric ganglion.
Reference:
1 . Stein W, DeMaegd ML, Braun LY, Vidal-Gadea A, Harris AL, Städele C (2022) The dynamic range of voltage-dependent gap junction signaling is maintained by Ih-induced membrane potential depolarization J Neurophysiology [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Stomatogastric ganglion;
Cell Type(s): Stomatogastric Ganglion (STG) Modulatory commissural neuron 1 (MCN1); Stomatogastric Ganglion (STG) Lateral Gastric (LG) cell; Hodgkin-Huxley neuron;
Channel(s): I h;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: Mathematica;
Model Concept(s): Invertebrate;
Implementer(s): Harris, Allison L; Stein, Wolfgang [wstein@ilstu.edu];
Search NeuronDB for information about:  I h;
 
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267286
                            
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