Acetylcholine Boosts Dendritic NMDA Spikes in a CA3 Pyramidal Neuron Model (Humphries et al., 2021)

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Accession:267298
This model was used to compare the nonlinearity of NMDA inputs between dendritic sections in a CA3 pyramidal neuron as well as investigate the effect of cholinergic modulation/potassium channel inhibition on this dendritic NMDA-mediated nonlinearity.
Reference:
1 . Humphries R, Mellor JR, O'Donnell C (2021) Acetylcholine Boosts Dendritic NMDA Spikes in a CA3 Pyramidal Neuron Model Neuroscience [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA3 pyramidal GLU cell;
Channel(s): I Potassium;
Gap Junctions:
Receptor(s): NMDA; AMPA;
Gene(s):
Transmitter(s): Acetylcholine;
Simulation Environment: NEURON; Python;
Model Concept(s): Active Dendrites; Dendritic Action Potentials; Detailed Neuronal Models; Neuromodulation;
Implementer(s): Humphries, Rachel;
Search NeuronDB for information about:  Hippocampus CA3 pyramidal GLU cell; AMPA; NMDA; I Potassium; Acetylcholine;
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