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A sensorimotor-spinal cord model (Hoshino et al. 2022)
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To elucidate how the flattening of sensory tuning due to a deficit in tonic inhibition slows motor responses, we simulated a neural network model in which a sensory cortical network (NS) and a motor cortical network (NM) are reciprocally connected, and the NM projects to spinal motoneurons (Mns). The NS was presented with a feature stimulus and the reaction time of Mns was measured. The flattening of sensory tuning in NS caused by decreasing the centration of GABA in extracellular space resulted in a decrease in the stimulus-sensitive NM pyramidal cell activity while increasing the stimulus-insensitive NM pyramidal cell activity, thereby prolonging the reaction time of Mns to the applied feature stimulus. We suggest that a reduction in extracellular GABA concentration in sensory cortex may interfere with selective activation in motor cortex, leading to slowing the activation of spinal motoneurons and therefore to slowing motor responses.
Hoshino O, Zheng M, Fukuoka Y (2022) Effect of cortical extracellular GABA on motor response
J Comput Neurosci
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