A focal seizure model with ion concentration changes (Gentiletti et al., 2022)

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Computer model was used to investigate the possible mechanisms of seizure initiation, progression and termination. The model was developed by complementing the Hodgkin-Huxley equations with activity-dependent changes in intra- and extracellular ion concentrations. The model incorporates a number of ionic mechanisms such as: active and passive membrane currents, inhibitory synaptic GABAA currents, Na/K pump, KCC2 cotransporter, glial K buffering, radial diffusion between extracellular space and bath, and longitudinal diffusion between dendritic and somatic compartments in pyramidal cells.
1 . Gentiletti D, de Curtis M, Gnatkovsky V, Suffczynski P (2022) Focal seizures are organized by feedback between neural activity and ion concentration changes eLife [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Extracellular;
Brain Region(s)/Organism: Entorhinal cortex;
Cell Type(s): Entorhinal cortex pyramidal cell; Entorhinal cortex fast-spiking interneuron;
Channel(s): Ca pump; I CAN; I Cl, leak; I K,Ca; I K,leak; I L high threshold; I M; I Na, leak; I Na,p; I Na,t; I_AHP; I_HCO3; KCC2; Na/K pump; Osmosis-driven water flux;
Gap Junctions:
Receptor(s): AMPA; GabaA;
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Epilepsy; Dynamic extracellular concentrations;
Implementer(s): Suffczynski, Piotr [Piotr.Suffczynski at fuw.edu.pl]; Gentiletti, Damiano [gentiletti.damiano at gmail.com];
Search NeuronDB for information about:  GabaA; AMPA; I Na,p; I Na,t; I L high threshold; I K,leak; I M; I K,Ca; I CAN; Na/K pump; I_AHP; I Cl, leak; I Na, leak; Osmosis-driven water flux; KCC2; Ca pump; I_HCO3; Gaba; Glutamate;
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