Axonal subthreshold voltage signaling along hippocampal mossy fiber (Kamiya 2022)

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Accession:267512
Subthreshold depolarization of soma passively propagates into the axons for a substantial distance and thereby caused enhancement of the transmitter release from the axon terminals of hippocampal mossy fibers. Here we developed the granule cell-mossy fiber model implemented with axonal sodium potassium and calcium channels and explored the mechanisms underlying analog modulation of the action potential-evoked transmitter release by subthreshold voltage signaling along the axons. Action potential-induced calcium entry to the terminals was reduced, while subthreshold depolarization itself caused small calcium entry.
Reference:
1 . Kamiya H (2022) Modeling analysis of subthreshold voltage signaling along hippocampal mossy fiber axons Front Cell Neurosci
Model Information (Click on a link to find other models with that property)
Model Type: Axon;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Dentate gyrus granule GLU cell;
Channel(s): I Calcium; I Sodium; I K;
Gap Junctions:
Receptor(s): AMPA; GabaA;
Gene(s):
Transmitter(s): Glutamate; Gaba;
Simulation Environment: NEURON;
Model Concept(s): Action Potentials; Axonal Action Potentials; Analog coding; Subthreshold signaling;
Implementer(s): Kamiya, Haruyuki [kamiya at med.hokudai.ac.j];
Search NeuronDB for information about:  Dentate gyrus granule GLU cell; GabaA; AMPA; I K; I Sodium; I Calcium; Gaba; Glutamate;
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objectvar save_window_, rvp_
objectvar scene_vector_[5]
objectvar ocbox_, ocbox_list_, scene_, scene_list_
{ocbox_list_ = new List()  scene_list_ = new List()}
{pwman_place(0,0,0)}

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load_file("pointman.hoc")
}
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mt.select("VClamp") i = mt.selected()
ms[i] = new MechanismStandard("VClamp")
ms[i].set("dur", 10, 0)
ms[i].set("dur", 20, 1)
ms[i].set("dur", 10, 2)
ms[i].set("amp", -80, 0)
ms[i].set("amp", 0, 1)
ms[i].set("amp", -80, 2)
ms[i].set("gain", 100000, 0)
ms[i].set("rstim", 1, 0)
ms[i].set("tau1", 0.001, 0)
ms[i].set("tau2", 0, 0)
ms[i].set("e0", 0.000799984, 0)
ms[i].set("vo0", -79.9984, 0)
ms[i].set("vi0", -79.9984, 0)
ms[i].set("fac", 0, 0)
mt.select("VClamp") i = mt.selected() maction(i)
hoc_ac_ = 0.5
sec.sec move() d1.flip_to(0)
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{object_pop() doNotify()}
{
ocbox_ = ocbox_.v1
ocbox_.map("PointProcessManager", 282, 122, 222.3, 216)
}
objref ocbox_
//End PointProcessManager

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v_init = -80
xvalue("Init","v_init", 1,"stdinit()", 1, 1 )
xbutton("Init & Run","run()")
xbutton("Stop","stoprun=1")
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xbutton("Single Step","steprun()")
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screen_update_invl = 0.05
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realtime = 0.02
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xpanel(0,121)
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save_window_.save_name("graphList[1].")
save_window_.addexpr("s.ica( 0.5 )", 4, 2, 0.8, 0.9, 2)
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save_window_ = new Graph(0)
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save_window_.save_name("graphList[0].")
save_window_.addexpr("v(.5)", 2, 2, 0.8, 0.9, 2)
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objectvar scene_vector_[1]
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