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Axonal subthreshold voltage signaling along hippocampal mossy fiber (Kamiya 2022)

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Accession:267512
Subthreshold depolarization of soma passively propagates into the axons for a substantial distance and thereby caused enhancement of the transmitter release from the axon terminals of hippocampal mossy fibers. Here we developed the granule cell-mossy fiber model implemented with axonal sodium potassium and calcium channels and explored the mechanisms underlying analog modulation of the action potential-evoked transmitter release by subthreshold voltage signaling along the axons. Action potential-induced calcium entry to the terminals was reduced, while subthreshold depolarization itself caused small calcium entry.
Reference:
1 . Kamiya H (2022) Modeling analysis of subthreshold voltage signaling along hippocampal mossy fiber axons Front Cell Neurosci
Model Information (Click on a link to find other models with that property)
Model Type: Axon;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Dentate gyrus granule GLU cell;
Channel(s): I Calcium; I Sodium; I K;
Gap Junctions:
Receptor(s): AMPA; GabaA;
Gene(s):
Transmitter(s): Glutamate; Gaba;
Simulation Environment: NEURON;
Model Concept(s): Action Potentials; Axonal Action Potentials; Analog coding; Subthreshold signaling;
Implementer(s): Kamiya, Haruyuki [kamiya at med.hokudai.ac.j];
Search NeuronDB for information about:  Dentate gyrus granule GLU cell; GabaA; AMPA; I K; I Sodium; I Calcium; Gaba; Glutamate;
´╗┐This is the readme for the modeling in the paper:
Kamiya H (2022) Modeling analysis of subthreshold voltage signaling along hippocampal mossy fiber axons.
 Front. Cell. Neurosci., https://www.frontiersin.org/articles/10.3389/fncel.2022.966636
In this paper, the models of the sodium, potassium, and calcium channels found in the hippocampal 
mossy fiber terminals were reconstructed according to the parameters described in the papers;
Engel D, Jonas P (2005) Presynaptic action potential amplification by voltage-gated Na+ channels in
 hippocampal mossy fiber boutons. Neuron 45: 405-17. http://dx.doi.org/10.1016/j.neuron.2004.12.048
and 
Li L, Josef Bischofberger J, Jonas P (2007) Differential gating and recruitment of P/Q-, N-, and R-type
 Ca2+ channels in hippocampal mossy fiber boutons. J. Neurosci.  27: 13420-9. https://www.jneurosci.org/content/27/49/13420
To test for the subthreshold axonal voltage signaling on spike propagation and transmitter release,
these models of axonal sodium, potassium, and calcium channel were implemented with
the structure model of mossy fiber and granule cells as described in;
Alle H, Geiger JR (2006) Combined analog and action potential coding in hippocampal mossy fibers. 
 Science, 311: 1290-3. https://www.science.org/doi/10.1126/science.1119055

To run the simulations, follow these steps:
Compile the mod files using nrnivmodl under Mac OS X and Linux, or mknrndll under Windows.
Run mosinit.hoc in NEURON.
Click the radiobuttons in the panel "Demo" and click "Init & Run" in the "RunControl" panel to run simulations.

Questions about this model should be directed to kamiya@med.hokudai.ac.jp.



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