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Axonal subthreshold voltage signaling along hippocampal mossy fiber (Kamiya 2022)

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Subthreshold depolarization of soma passively propagates into the axons for a substantial distance and thereby caused enhancement of the transmitter release from the axon terminals of hippocampal mossy fibers. Here we developed the granule cell-mossy fiber model implemented with axonal sodium potassium and calcium channels and explored the mechanisms underlying analog modulation of the action potential-evoked transmitter release by subthreshold voltage signaling along the axons. Action potential-induced calcium entry to the terminals was reduced, while subthreshold depolarization itself caused small calcium entry.
1 . Kamiya H (2022) Modeling analysis of subthreshold voltage signaling along hippocampal mossy fiber axons Front Cell Neurosci
Model Information (Click on a link to find other models with that property)
Model Type: Axon;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Dentate gyrus granule GLU cell;
Channel(s): I Calcium; I Sodium; I K;
Gap Junctions:
Receptor(s): AMPA; GabaA;
Transmitter(s): Glutamate; Gaba;
Simulation Environment: NEURON;
Model Concept(s): Action Potentials; Axonal Action Potentials; Analog coding; Subthreshold signaling;
Implementer(s): Kamiya, Haruyuki [kamiya at];
Search NeuronDB for information about:  Dentate gyrus granule GLU cell; GabaA; AMPA; I K; I Sodium; I Calcium; Gaba; Glutamate;
xlabel("To run simulations, click the radiobuttons.")
xradiobutton("Axonal INa (Fig.1A)", "restart() load_file(\"Test_mfbhh_na.hoc\")")
xradiobutton("Axonal IK (Fig.1B)", "restart() load_file(\"Test_mfbhh_k.hoc\")")
xradiobutton("Axonal ICaPQ (Fig.1C)", "restart() load_file(\"Test_mfbpq_ca.hoc\")")
xradiobutton("Axonal ICaN (Fig.1D)", "restart() load_file(\"Test_mfbn_ca.hoc\")")
xradiobutton("Axonal ICaR (Fig.1E)", "restart() load_file(\"Test_mfbr_ca.hoc\")")
xradiobutton("EPreSP propagation (Fig.2A)", "restart() load_file(\"EPreSP_propagation.hoc\")")
xradiobutton("AP propagation (Fig.2C)", "restart() load_file(\"AP_propagation.hoc\")")
xradiobutton("Ca entry by AP (Fig.3A)", "restart() load_file(\"AP.hoc\")")
xradiobutton("Ca entry by EPreSP & AP (Fig. 3B)", "restart() load_file(\"EPreSP+AP.hoc\")")
xradiobutton("Ca entry by EPreSP (Fig. 3E)", "restart() load_file(\"EPreSP.hoc\")")
xradiobutton("Ca entry by AP (Fig. 4B)", "restart() load_file(\"AP2.hoc\")")
xradiobutton("Ca entry by GABA-EPreSP & AP (Fig. 4C)", "restart() load_file(\"GABA-EPreSP+AP.hoc\")")
xradiobutton("Ca entry by GABA-EPreSP (Fig. 4E)", "restart() load_file(\"GABA-EPreSP.hoc\")")
xpanel(20, 560)
proc restart() {objectvar graphList[n_graph_lists], RunControl, graphItem, flush_list
for i=0,n_graph_lists-1 graphList[i] = new List(1)
flush_list = new List(1)
tempobj = new List("PointProcessManager")
while (tempobj.count()) {tempobj.object(0).v1.unmap()}}

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