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Olfactory Bulb Network (Davison et al 2003)

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A biologically-detailed model of the mammalian olfactory bulb, incorporating the mitral and granule cells and the dendrodendritic synapses between them. The results of simulation experiments with electrical stimulation agree closely in most details with published experimental data. The model predicts that the time course of dendrodendritic inhibition is dependent on the network connectivity as well as on the intrinsic parameters of the synapses. In response to simulated odor stimulation, strongly activated mitral cells tend to suppress neighboring cells, the mitral cells readily synchronize their firing, and increasing the stimulus intensity increases the degree of synchronization. For more details, see the reference below.
1 . Davison AP, Feng J, Brown D (2003) Dendrodendritic inhibition and simulated odor responses in a detailed olfactory bulb network model. J Neurophysiol 90:1921-35 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Olfactory bulb;
Cell Type(s): Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron granule MC GABA cell;
Channel(s): I Na,t; I L high threshold; I A; I K; I K,leak; I M; I K,Ca; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Oscillations; Synchronization; Spatio-temporal Activity Patterns; Olfaction;
Implementer(s): Davison, Andrew [Andrew.Davison at];
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron granule MC GABA cell; GabaA; AMPA; NMDA; I Na,t; I L high threshold; I A; I K; I K,leak; I M; I K,Ca; I Sodium; I Calcium; I Potassium; Gaba; Glutamate;
cadecay.mod *
flushf.mod *
kA.mod *
kca.mod *
kfasttab.mod *
kM.mod *
kslowtab.mod *
lcafixed.mod *
nafast.mod *
nagran.mod *
nmdanet.mod *
calcisilag.hoc *
ddi_baseline.gnu * *
experiment_ddi_baseline.hoc *
experiment_odour_baseline.hoc *
granule.tem *
init.hoc *
input.hoc *
input1 *
mathslib.hoc *
mitral.tem *
mosinit.hoc *
odour_baseline.gnu * *
parameters_ddi_baseline.hoc *
parameters_odour_baseline.hoc *
screenshot.png *
tabchannels.dat *
tabchannels.hoc *
// init.hoc
// Olfactory bulb network model: initialisation file
// Andrew Davison, The Babraham Institute, 2000.

objref exptBox, ctrlBox
strdef filename
quitmodel = 0

exptBox = new VBox()
    xlabel("Choose an experiment:")
    xradiobutton("Response to olfactory nerve shock (Fig. 2)", "run_experiment(\"ddi_baseline\")")
    xradiobutton("Response to odour stimulus (Fig. 8)","run_experiment(\"odour_baseline\")")
exptBox.intercept(0)"Olfactory bulb network model",0,80,-1,-1)

proc run_experiment() {
  ctrlBox = new VBox()
    xlabel("The network is being created. This may take some time.")
  ctrlBox.intercept(0)"Olfactory bulb network model",0,80,-1,-1)
  xopen("mathslib.hoc")			// mathematical procedures
  print "Reading channel tables"
  xopen("tabchannels.hoc")		// channel tables
  print "Reading mitral cell template"
  xopen("mitral.tem") 			// mitral cell template
  print "Reading granule cell template"
  xopen("granule.tem")			// granule cell template
  print "Reading parameters"
  xopen(filename)                       // model parameters
  print "Creating network"
  xopen("bulb.hoc")			// model set-up
  print "Reading input procedures"
  xopen("input.hoc")			// define procedures to set-up input
  print "Setting-up experiment"
  xopen(filename)                       // which parameters to record
  ctrlBox = new VBox()
    xlabel("* To run the simulation, click on [Init & Run].")
    xlabel("* When the simulation is complete, click on [Save Results].")
    xlabel("* If you wish to run a different experiment, you will have")
    xlabel("   to quit NEURON and restart.")
    xlabel(" ")
    xbutton("Save results","print_results()")
  ctrlBox.intercept(0)"Olfactory bulb network model",0,80,-1,-1)
  print "Initialisation complete"
  print ""
  print "To run the simulation, click on [Init & Run]."
  print "When the simulation is complete, click on [Save Results]."
  print "If you have gnuplot ( installed"
  print "on your computer, you can produce a figure by running"
  print "gnuplot with the file ", $s1, ".gnu"

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