Low Threshold Calcium Currents in TC cells (Destexhe et al 1998)

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Accession:279
In Destexhe, Neubig, Ulrich, and Huguenard (1998) experiments and models examine low threshold calcium current's (IT, or T-current) distribution in thalamocortical (TC) cells. Multicompartmental modeling supports the hypothesis that IT currents have a density at least several fold higher in the dendrites than the soma. The IT current contributes significantly to rebound bursts and is thought to have important network behavior consequences. See the paper for details. See also http://cns.iaf.cnrs-gif.fr Correspondance may be addressed to Alain Destexhe: Destexhe@iaf.cnrs-gif.fr
Reference:
1 . Destexhe A, Neubig M, Ulrich D, Huguenard J (1998) Dendritic low-threshold calcium currents in thalamic relay cells. J Neurosci 18:3574-88 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Thalamus geniculate nucleus/lateral principal GLU cell;
Channel(s): I Na,t; I T low threshold; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Bursting; Ion Channel Kinetics; Parameter Fitting; Simplified Models; Influence of Dendritic Geometry; Detailed Neuronal Models; Calcium dynamics; Rebound firing;
Implementer(s): Destexhe, Alain [Destexhe at iaf.cnrs-gif.fr];
Search NeuronDB for information about:  Thalamus geniculate nucleus/lateral principal GLU cell; I Na,t; I T low threshold; I K;
/*----------------------------------------------------------------

  Geometry file for thalamocortical neuron

  - 1 compartment (soma)

  Length and diameters:
  ---------------------

	Soma :		L=100		diam=76.58

	=> total dendritic surface = 24058 um2
	   Reconstructed cell was of 23980.547 um2

The determination of the size of this single-compartment neuron, the
evaluation of its passive parameters, its cable properties and how this neuron
matches the physiology of thalamic relay cells are described in:

      Destexhe A, Neubig M, Ulrich D and Huguenard JR.  Dendritic
      low-threshold calcium currents in thalamic relay cells.  
      J. Neurosci. 18: 3574-3588, 1998.
      http://cns.fmed.ulaval.ca

----------------------------------------------------------------*/

print "----------------------------------------------"
print "   Single-compartment TC cell model"
print "----------------------------------------------"


/* create compartments (sections) */

create soma[1]

soma {
  nseg = 1
  diam = 76.58			// obtained by fitting passive responses
  L = 100
  cm = 1
}


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