| Accession:33986 |
The present study investigated how the modulation of these currents altered the spike duration
and excitability of sensory neurons and examined the relative contributions
of PKA- and PKC-mediated effects to the actions of 5-HT. A
Hodgkin-Huxley type model was developed that described the ionic
conductances in the somata of sensory neurons. The descriptions of
these currents and their modulation were based largely on voltageclamp
data from sensory neurons. Simulations were preformed with
the program SNNAP (Simulator for Neural Networks and Action
Potentials). The model was sufficient to replicate empirical data that
describes the membrane currents, action potential waveform and
excitability as well as their modulation by application of 5-HT,
increased levels of adenosine cyclic monophosphate or application of
active phorbol esters. The results provide
several predictions that warrant additional experimental investigation
and illustrate the importance of considering indirect as well as direct
effects of modulatory agents on the modulation of membrane currents. See paper for more details.
Reference:
1 .
Baxter DA, Canavier CC, Clark JW, Byrne JH (1999) Computational model of the serotonergic modulation of sensory neurons in Aplysia. J Neurophysiol 82:2914-35 [PubMed]
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