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Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)
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It has been found that in cultured Aplysia neurons bath applications of 40 mM cafffeine evokes oscillations of the membrane potential with about a 40 mV amplitude with a frequency of 0.2 to 0.5 Hz. The most probable mechanism of these caffeine-induced oscillations is inhibition of voltage-activated outward potassium current and, as can be seen from our mathematical modeling, slowdown of inactivation of inward sodium current. It seems likely that these oscillations have a purely membrane origin. Please see paper for results and details.
Komendantov AO, Kononenko NI (2000) Caffeine-induced oscillations of the membrane potential in Aplysia Neurons.
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Neuron or other electrically excitable cell;
Aplysia cultured neuron;
Komendantov, Alexander O [akomenda at tulane.edu];
Kononenko, Nikolai I [nik137 at lamar.colostate.edu];
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