Multiple modes of a conditional neural oscillator (Epstein, Marder 1990)

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Accession:42321
We present a model for a conditional bursting neuron consisting of five conductances: Hodgkin-Huxley type time- and voltage-dependent Na+ and K+ conductances, a calcium activated voltage-dependent K+ conductance, a calcium-inhibited time- and voltage-dependent Ca++ conductance, and a leakage Cl- conductance. Different bursting and silent modes and transitions between them are analyzed in the model and compared to bursting modes in experiment. See the paper for details.
Reference:
1 . Epstein IR, Marder E (1990) Multiple modes of a conditional neural oscillator. Biol Cybern 63:25-34 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I Chloride; I Na,t; I K; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: SNNAP;
Model Concept(s): Bursting; Invertebrate;
Implementer(s): Baxter, Douglas;
Search NeuronDB for information about:  I Chloride; I Na,t; I K; I Sodium; I Calcium; I Potassium;
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  LOGICAL_NAME:		> 	Name of Network		>
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  Epstein_etal_1990	> The name of the network	>
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  TIMING:		> Timing information in seconds	>
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	0.0		> What value to assign to the	>
			> variable "time" at time=0	>
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	4000.0		> When to stop the simulation	>
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	0.002		> Step-size (h)			>
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  ON_LINE_GRAPH:	> 	On-line graph		>
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	1		> 1 for yes, 0 for no		>
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  STORE_RESULTS:	> 	Store results		>
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	0		> 1 for yes, 0 for no		>
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  INT_METHOD:		> 	Integration method	>
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	1		> 1 for Euler method		>
			> 2 for RK			>
			> 3 for RKQC			>
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  NETWORK:		> structure of network		>
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	Epstein.ntw	> the name of the file 		>
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  OUTPUT_SETUP:		> list of variables for output	>
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	Epstein.ous	> the name of the file 		>
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  TREATMENTS:		> External treatments		>
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	Epstein.trt	> the name of the file 		>
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