Olfactory receptor neuron model (Dougherty et al 2005)

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Accession:54896
Demonstration of ORN model by Dougherty, Wright and Yew (2005) PNAS 102: 10415-10420. This program, dwy_pnas_demo2, simulates the transduction current response of a single olfactory receptor neuron being stimulated by an odorant plume. The program is interactive in that a user can tweak parameter values and stimulus conditions. Also, users can save a configuration in a mat-file or export all aspects to a directory of text files. These text files can be read by other programs. There is also an import facility for importing text files from a directory that allows the user to specify their own data, pulses and parameters.
Reference:
1 . Dougherty DP, Wright GA, Yew AC (2005) Computational model of the cAMP-mediated sensory response and calcium-dependent adaptation in vertebrate olfactory receptor neurons. Proc Natl Acad Sci U S A 102:10415-20 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Olfactory receptor GLU cell;
Channel(s): I K,leak; I Cl,Ca; I CNG;
Gap Junctions:
Receptor(s): Olfactory Receptors;
Gene(s):
Transmitter(s):
Simulation Environment: MATLAB;
Model Concept(s): Activity Patterns; Ion Channel Kinetics; Oscillations; Parameter Fitting; Simplified Models; Olfaction;
Implementer(s): Dougherty, Daniel P [dpdoughe at mbi.ohio-state.edu]; Wright, Geraldine A [wright.571 at osu.edu]; Yew, Alice C [yew at math.ohio-state.edu];
Search NeuronDB for information about:  Olfactory receptor GLU cell; Olfactory Receptors; I K,leak; I Cl,Ca; I CNG;
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dwy_pnas_demo2
readme
dwy_pnas_demo2.m
                            
This is a readme file for the models associated with

Dougherty, Wright and Yew (2005) Computational model of the
cAMP-mediated sensory response and calcium-dependent 
adaptation in vertebrate olfactory receptor neurons. 
PNAS 2005 Jul 26;102(30):10415-20.

Example use of the model files:

1)download and expand the zip file.
2)Start matlab.
3)Within matlab, cd to the directory created when the zip 
  file was expanded (for example I expanded the zip file in
  c:/nrnmodels):
  >> cd c:/nrnmodels/dwy_pnas_demo2/
  or alternatively add that file to your matlab path.
4)Run the program by typing the name at the matlab prompt

>> dwy_pnas_demo2
5) select single and press ok a few times to create fig 1a,1b
from the paper.

Dougherty's web site: http://mbi.osu.edu/~dpdoughe

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