The model of type II cochlear ganglion cell was based on the
immunostaining of the mouse auditory pathway. Specific antibodies were
used to map the distribution of voltage-dependent sodium channels along
the two unmyelinated axon-like processes of the bipolar ganglion cells.
Three distinct hot spots were detected. A high density of sodium
channels was present over the entire trajectory of sensory endings
beneath the outer hair cells (the most distal portion of the peripheral
axon). The other two hot spots were localized in the initial segments of
both of the axons that flank the unmyelinated bipolar ganglion cell bodies.
A biophysical model indicates that all three hot spots might play
important roles in action potential initiation and propagation. For
instance, the hot spot in the receptor segment is important for
transforming the receptor potentials into a full blown action potential
(Supplemental Fig. 1). The hot spots in the two paraganglionic axon
initial segments are there to ensure the successful propagation of
action potentials from the peripheral to the central axon through the
cell body.
The Readme.txt file provides step by step instructions on how to
recreate Figures 6 and 7 of Hossain et al., 2005 paper.
Reference:
1 .
Hossain WA, Antic SD, Yang Y, Rasband MN, Morest DK (2005) Where is the spike generator of the cochlear nerve? Voltage-gated sodium channels in the mouse cochlea. J Neurosci 25:6857-68 [PubMed]
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