Breakdown of accmmodation in nerve: a possible role for INAp (Hennings et al 2005)

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The present modeling study suggests that persistent, low-threshold, rapidly activating sodium currents have a key role in breakdown of accommodation, and that breakdown of accommodation can be used as a tool for studying persistent sodium current under normal and pathological conditions. See paper for more and details.
1 . Hennings K, Arendt-Nielsen L, Andersen OK (2005) Breakdown of accommodation in nerve: a possible role for persistent sodium current. Theor Biol Med Model 2:16 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Spinal cord lumbar motor neuron alpha ACh cell; Myelinated neuron;
Channel(s): I Na,p; I Na,t; I K;
Gap Junctions:
Simulation Environment: MATLAB;
Model Concept(s): Action Potential Initiation; Action Potentials; Pathophysiology; Electrotonus;
Implementer(s): Hennings, Kristian [krist at];
Search NeuronDB for information about:  Spinal cord lumbar motor neuron alpha ACh cell; I Na,p; I Na,t; I K;
function [R,T] = SDstat(M,Idc)
%SDstat Strength-Duration Statistics (Rheobase and SD-Time)
%   [R,T] = SDstat(M,Idc) this function estimates the statistics of the strength-
%   duration curve with Weiss's law. It returns the rheobase [R] and the 
%   strength-duration time constant (SD-Time). These are estimated for a 
%   model [M].

%Definition of the two stimulus durations
%ts = [25e-6 50e-6 100e-6 200e-6 400e-6 800e-6 1600e-6 10e-3 20e-3 100e-3]';

%Create the parameters for the excitation function
Imax = 10e-9; Nmsi = 5; Itol = 0.0001e-9; noAP = 1; tspan = [0 1e-3];

S = pulse(0,10e-3);
S = setDC(S,Idc);
R = excitation(Imax,Nmsi,Itol,noAP,[0 11e-3],M,S);
T = chronaxie(1e-3,1e-6,M,2*R,0);
disp(sprintf('Rheobase: %.3fnA  / SD-Time Constant : %.2fus',R*1e9,T*1e6));

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