Breakdown of accmmodation in nerve: a possible role for INAp (Hennings et al 2005)

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Accession:55749
The present modeling study suggests that persistent, low-threshold, rapidly activating sodium currents have a key role in breakdown of accommodation, and that breakdown of accommodation can be used as a tool for studying persistent sodium current under normal and pathological conditions. See paper for more and details.
Reference:
1 . Hennings K, Arendt-Nielsen L, Andersen OK (2005) Breakdown of accommodation in nerve: a possible role for persistent sodium current. Theor Biol Med Model 2:16 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Spinal cord lumbar motor neuron alpha ACh cell; Myelinated neuron;
Channel(s): I Na,p; I Na,t; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: MATLAB;
Model Concept(s): Action Potential Initiation; Action Potentials; Pathophysiology; Electrotonus;
Implementer(s): Hennings, Kristian [krist at hst.auc.dk];
Search NeuronDB for information about:  Spinal cord lumbar motor neuron alpha ACh cell; I Na,p; I Na,t; I K; 
function [E,E0] = recovery(Tisi,M,Idc,Irel,Ts)
%RECOVERY Simulate the recovery cycle
%   [E,E0] = recovery(Tisi,M,Idc,Irel)

%PART 1: Find the excitation threshold for the conditioning pulse
%Ts = 1e-3;
Imax = 10e-9; Nmsi = 10; Itol = 1e-14;
S = pulse(0,Ts);
S = setDC(S,Idc);
E0 = excitation(Imax,Nmsi,Itol,1,[0 2e-3],M,S);        

%PART 2: Simulate the recovery cycle
MSAVE = M;
for n = 1:length(Tisi)
    M = MSAVE;
    S = pulse(-E0*Irel,Ts);
    S = setDC(S,Idc);
    if Tisi(n) ~= 0
        M.X0 = x0patch([0 Tisi(n)],S,M);
    end
   
    E(n) = excitation(Imax,Nmsi,Itol,1,[0 2e-3],M,S);      
    %fprintf('.');
end

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