Breakdown of accmmodation in nerve: a possible role for INAp (Hennings et al 2005)

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The present modeling study suggests that persistent, low-threshold, rapidly activating sodium currents have a key role in breakdown of accommodation, and that breakdown of accommodation can be used as a tool for studying persistent sodium current under normal and pathological conditions. See paper for more and details.
1 . Hennings K, Arendt-Nielsen L, Andersen OK (2005) Breakdown of accommodation in nerve: a possible role for persistent sodium current. Theor Biol Med Model 2:16 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Spinal cord lumbar motor neuron alpha ACh cell; Myelinated neuron;
Channel(s): I Na,p; I Na,t; I K;
Gap Junctions:
Simulation Environment: MATLAB;
Model Concept(s): Action Potential Initiation; Action Potentials; Pathophysiology; Electrotonus;
Implementer(s): Hennings, Kristian [krist at];
Search NeuronDB for information about:  Spinal cord lumbar motor neuron alpha ACh cell; I Na,p; I Na,t; I K;
function [APs,t,En,Ei,Is,Xn,Xi,In,Ii] = resp(tspan,Fs,M,S)
%RESP Test the response to a stimulus
%   [APs,t,En,Ei,Is,Xn,Xi,In,Ii] = resp(tspan,Fs,M,S)
h = 2e-6;
P = parameters(tspan(1),tspan(2),h,Fs,0,1);

tspan = [0e-3 2e-3];
h = 1e-6;
APs = simPatch(P,S,M.E,M.GN,M.GI,M.A,M.B,M.X0);
load data.out
t  = data(:,1);
En = data(:,2);
Ei = data(:,3);
Is = data(:,4);
Xn = data(:,5:9);
Xi = data(:,10:12);
In = data(:,13:16);
Ii = data(:,17:18);

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