Breakdown of accmmodation in nerve: a possible role for INAp (Hennings et al 2005)

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Accession:55749
The present modeling study suggests that persistent, low-threshold, rapidly activating sodium currents have a key role in breakdown of accommodation, and that breakdown of accommodation can be used as a tool for studying persistent sodium current under normal and pathological conditions. See paper for more and details.
Reference:
1 . Hennings K, Arendt-Nielsen L, Andersen OK (2005) Breakdown of accommodation in nerve: a possible role for persistent sodium current. Theor Biol Med Model 2:16 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Spinal cord lumbar motor neuron alpha ACh cell; Myelinated neuron;
Channel(s): I Na,p; I Na,t; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: MATLAB;
Model Concept(s): Action Potential Initiation; Action Potentials; Pathophysiology; Electrotonus;
Implementer(s): Hennings, Kristian [krist at hst.auc.dk];
Search NeuronDB for information about:  Spinal cord lumbar motor neuron alpha ACh cell; I Na,p; I Na,t; I K; 
function [T,V,E0] = si(Tp,M,I)
%SI Strength-Intensity test
%   [T,V,E0] = si(Tp,M,I)

Imax = 10e-9; Nmsi = 10; Itol = 0.0001e-9; noAP = 1; 

[Spls] = pulse(0,1e-3);  
Spls = setDC(Spls,0);
E0 = excitation(Imax,Nmsi,Itol,noAP,[0 2e-3],M,Spls);        

MSAVE = M;
for n = 1:length(I)
    M = MSAVE;
    S = ramp(-I(n),Tp);
    S = setDC(S,0);
    M.X0 = x0patch([0 Tp],S,M); 
    V(n) = M.X0(1);
    T(n) = excitation(Imax,Nmsi,Itol,noAP,[0 2e-3],M,Spls);     
    fprintf('.');
end

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