A model for pituitary GH(3) lactotroph (Wu and Chang 2005)

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The ATP-sensitive K(+) (K(ATP)) channels are composed of sulfonylurea receptor and inwardly rectifying K(+) channel (Kir6.2) subunit. These channels are regulated by intracellular ADP/ATP ratio and play a role in cellular metabolism. ... The objective of this study was to determine whether Diethyl pyrocarbonate (DEPC) modifies K(ATP)-channel activity in pituitary GH(3) cells. ... Simulation studies also demonstrated that the increased conductance of K(ATP)-channels used to mimic DEPC actions reduced the frequency of spontaneous action potentials and fluctuation of intracellular Ca(2+). The results indicate that chemical modification with DEPC enhances K(ATP)-channel activity and influences functional activities of pituitary GH(3) cells. See paper for more and details.
1 . Wu SN, Chang HD (2006) Diethyl pyrocarbonate, a histidine-modifying agent, directly stimulates activity of ATP-sensitive potassium channels in pituitary GH(3) cells. Biochem Pharmacol 71:615-23 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Pituitary cell;
Channel(s): I K; I K,Ca; I Potassium; ATP-senstive potassium current;
Gap Junctions:
Receptor(s): IP3;
Gene(s): Kir6.2 KCNJ11;
Simulation Environment: XPPAUT;
Model Concept(s): Activity Patterns; Ion Channel Kinetics; Action Potentials;
Implementer(s): Wu, Sheng-Nan [snwu at mail.ncku.edu.tw]; Chang, Han-Dong;
Search NeuronDB for information about:  IP3; I K; I K,Ca; I Potassium; ATP-senstive potassium current;
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