A mathematical model of the membrane action potential of the mammalian
ventricular cell is introduced. The model is based, whenever possible,
on recent single-cell and single-channel data and incorporates the
possibility of changing extracellular potassium concentration [K]o. The
fast sodium current, INa, is characterized by fast upstroke velocity (Vmax
= 400 V/sec) and slow recovery from inactivation. The time-independent
potassium current, IK1, includes a negative-slope phase and displays
significant crossover phenomenon as [K]o is varied. The time-dependent
potassium current, IK, shows only a minimal degree of crossover. A novel
potassium current that activates at plateau potentials is included in
the model. The simulated action potential duplicates the experimentally
observed effects of changes in [K]o on action potential duration and rest
potential. See papers for more and details.
References:
1 .
Luo CH, Rudy Y (1991) A model of the ventricular cardiac action potential. Depolarization, repolarization, and their interaction. Circ Res 68:1501-26 [PubMed]
2 .
Wu SN (2004) Simulations of the cardiac action potential based on the Hodgkin-Huxley kinetics with the use of Microsoft Excel spreadsheets. Chin J Physiol 47:15-22 [PubMed]
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