Find models by
Find models for
Find models of
Electrical synapses (gap junctions)
SenseLab mailing list
ModelDB related resources
Computational neuroscience ecosystem
Models in a git repository
ModelDB is moving. Check out our new site at
The corresponding page is
Regulation of the firing pattern in dopamine neurons (Komendantov et al 2004)
Download zip file
Help downloading and running models
Versions on GitHub
Midbrain dopaminergic (DA) neurons in vivo exhibit two major firing patterns: single-spike firing and burst firing. The firing pattern expressed is dependent on both the intrinsic properties of the neurons and their excitatory and inhibitory synaptic inputs. Experimental data suggest that the activation of NMDA and GABAA receptors is crucial contributor to the initiation and suppression of burst firing, respectively, and that blocking calcium-activated potassium channels can facilitate burst firing. This multi-compartmental model of a DA neuron with a branching structure was developed and calibrated based on in vitro experimental data to explore the effects of different levels of activation of NMDA and GABAA receptors as well as the modulation of the SK current on the firing activity.
Komendantov AO, Komendantova OG, Johnson SW, Canavier CC (2004) A modeling study suggests complementary roles for GABAA and NMDA receptors and the SK channel in regulating the firing pattern in midbrain dopamine neurons.
(Click on a link to find other models with that property)
Neuron or other electrically excitable cell;
Substantia nigra pars compacta DA cell;
Detailed Neuronal Models;
Kuznetsova, Anna [anna.kuznetsova at utsa.edu];
for information about:
Substantia nigra pars compacta DA cell
Download the displayed file
Other models using stim.mod:
CA1 pyramidal neuron (Combe et al 2018)
ModelDB scripts have detected that binary file '/damodel/state.old' is not displayable. You may download the file to examine if desired.
<- Select file from this column.
Load Model View
Loading data, please wait...