Synaptic integration of an identified nonspiking interneuron in crayfish (Takashima et al 2006)

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Accession:84599
This GENESIS simulation shows how a single or compound excitatory synaptic potential evoked by mechanosensory stimulation spreads over the dendrites of the LDS interneuron that is one of the identified nonspiking interneurons in the central nervous system of crayfish Procambarus clarkii. The model is based on physiological experiments carried out by Akira Takashima using single-electrode voltage clamp techniques and also 3-D morphometry of the interneuron carried out by Ryou Hikosaka using confocal laser scanning microscopic techniques. The physiological and morphological studies were coordinated by Masakazu Takahata.
References:
1 . Takashima A, Hikosaka R, Takahata M (2006) Functional significance of passive and active dendritic properties in the synaptic integration by an identified nonspiking interneuron of crayfish. J Neurophysiol 96:3157-69 [PubMed]
2 . Takahata M, Takashima A, Hikosaka R (2000) Information processing by nonspiking interneurons: passive and active properties of dendritic membrane determine synaptic integration. Biosystems 58:143-9 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Crayfish identified nonspiking interneuron;
Channel(s): I A; I K; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Influence of Dendritic Geometry; Invertebrate; Synaptic Integration;
Implementer(s): Takahata, Masakazu [takahata at sci.hokudai.ac.jp];
Search NeuronDB for information about:  I A; I K; I Potassium; 
//genesis - TEST.g - GENESIS Version 2.1
// This file was developed by
//       Akira Takashima.
//       Department of Biological Sciences
//       Faculry of Science
//       Hokkaido University
//       Sapporo Japan
//
//       Last update on 22 Jan. 2007


/*=======================================================================
  A sample script to create a multicompartment model containing channels
  taken from LDS_tab_chen.g  SI units are used.
  =======================================================================*/

include LDSdefs.g
include control.g
include xtools.g
include outputs.g
include inputs.g
include popup.g
include setcolors.g
include xgraph.g
include xcell.g
include option.g



float tmax = 100           // simulation time in msec, usually 200 msec  
float dt = 0.01         // simulation timestep in msec
setclock  0  {dt}          // set the simulation clock


function make_hsolve
    pushe /
    if ({exists /cell/solve})
        echo "/cell/solve  already exists!" 	
    else
        create hsolve /cell/solve  
        setfield /cell/solve path /cell/soma[TYPE=compartment],/cell/dend[][TYPE=compartment]
        setfield /cell/solve chanmode 4  comptmode 1
    
        call /cell/solve SETUP
        reset
        pope
        echo "create /cell/solve"
    end
end


//=================================
//          Main Script
//=================================
readcell LDS_active.p  /cell



setfield /cell/soma initVm -60     //milliVolts


makeinputs

setclock 1 0.5

// make the control panel
load_menus
setfield /output/control/stepsize value 0.01    // modified original


XCellCreate

XGraphCreate


change_soma

change_dend

setclock 2 0.5
setclock 3 0.01


check

make_hsolve

colorize

reset 


 
//EOF

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