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Models of Na channels from a paper on the PKC control of I Na,P (Baker 2005)
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"The tetrodotoxin-resistant (TTX-r) persistent Na(+) current, attributed to Na(V)1.9, was recorded in small (< 25 mum apparent diameter) dorsal root ganglion (DRG) neurones cultured from P21 rats and from adult wild-type and Na(V)1.8 null mice. ... Numerical simulation of the up-regulation qualitatively reproduced changes in sensory neurone firing properties. ..." Note: models of NaV1.8 and NaV1.9 and also persistent and transient Na channels that collectively model Nav 1.1, 1.6, and 1.7 are present in this model.
Baker MD (2005) Protein kinase C mediates up-regulation of tetrodotoxin-resistant, persistent Na+ current in rat and mouse sensory neurones.
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Neuron or other electrically excitable cell;
Dorsal Root Ganglion (DRG) cell;
Nav1.9 SCN11A SCN12A;
Ion Channel Kinetics;
Morse, Tom [Tom.Morse at Yale.edu];
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