Amyloid beta (IA block) effects on a model CA1 pyramidal cell (Morse et al. 2010)

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Accession:87284
The model simulations provide evidence oblique dendrites in CA1 pyramidal neurons are susceptible to hyper-excitability by amyloid beta block of the transient K+ channel, IA. See paper for details.
Reference:
1 . Morse TM, Carnevale NT, Mutalik PG, Migliore M, Shepherd GM (2010) Abnormal Excitability of Oblique Dendrites Implicated in Early Alzheimer's: A Computational Study. Front Neural Circuits [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I h; I K,Ca;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Active Dendrites; Detailed Neuronal Models; Pathophysiology; Aging/Alzheimer`s;
Implementer(s): Carnevale, Ted [Ted.Carnevale at Yale.edu]; Morse, Tom [Tom.Morse at Yale.edu];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I h; I K,Ca;
% remove10s.m
% this script removes type 10 from the cell morph in c

% find out how many type 10s there are

type10s=0;

for i=1:length(c)
  if (c(i,2)==10)
    type10s = type10s + 1;
% disp(['removing number ' int2str(type10s)]);

  end
end

removeme=zeros(1,type10s);

removeindex=1;
for i=1:length(c)
  if (c(i,2)==10)
    removeme(removeindex)=i;
removeindex = removeindex+1;
% disp(['removing number ' int2str(type10s)]);

  end
end

current_matrix=c;
for i=type10s:-1:1
  disp(['deleteing row ' int2str(removeme(i))])
  new_matrix=delrow(removeme(i), current_matrix);
current_matrix = new_matrix;
end

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