"... We have shown earlier that the
duration and amplitude of a prolonged depolarization alter all the steady state and kinetic parameters of rNav1.2a voltage gated Na
channel in a pseudo-oscillatory fashion. In the present study, we show that the Hodgkin–Huxley voltage and time dependent rate constants
of activation (am and bm) and fast inactivation (ah and bh), obtained from the analyses of Na currents and steady state activation
and inactivation plots, following application of prepulses in both slow (1–100 s) and fast (100–1000 ms) ranges, vary with the duration of
a prepulse in a pseudo-oscillatory manner. ..."
Reference:
1 .
Majumdar S, Sikdar SK (2007) Periodicity in Na+ channel properties alters excitability of a model neuron Biochem Biophys Res Commun.
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