Fast-spiking cortical interneuron (Golomb et al. 2007)

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Cortical fast-spiking (FS) interneurons display highly variable electrophysiological properties. We hypothesize that this variability emerges naturally if one assumes a continuous distribution of properties in a small set of active channels. We construct a minimal, single-compartment conductance-based model of FS cells that includes transient Na+, delayed-rectifier K+, and slowly inactivating d-type K+ conductances. The model may display delay to firing. Stuttering (elliptic bursting) and subthreshold oscillations may be observed for small Na+ window current.
1 . Golomb D, Donner K, Shacham L, Shlosberg D, Amitai Y, Hansel D (2007) Mechanisms of firing patterns in fast-spiking cortical interneurons. PLoS Comput Biol 3:e156 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex fast spiking (FS) interneuron;
Channel(s): I Na,t; I K; I A, slow; I_KD;
Gap Junctions:
Simulation Environment: NEURON; XPPAUT;
Model Concept(s): Bursting; Action Potentials; Stuttering; Delay;
Search NeuronDB for information about:  I Na,t; I K; I A, slow; I_KD;
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