This is the readme for the model code associated with the paper: Tseng SH, Tsai LY, Yeh SR (2008) Induction of high-frequency oscillations in a junction-coupled network. J Neurosci 28:7165-73 These model files were supplied by Shin-Hua Tseng. Usage notes: The simulation model code was created in NEURON 6.2 (NEURON is available from http://www.neuron.yale.edu) Follow the below procedure to easily observe oscillation results: Either auto-launch from ModelDB or download and extract the archive and then under mswin: ------ Compile the mod files by running mknrndll ([Start]->[Programs]->[Neuron 6.2]->[mknrndll]), cd'ing to the extracted folder and selecting to make the nrnmech.dll file. Then start the simulation by double clicking on the mosinit.hoc file while using the windows explorer or run [Start]->[Programs]->[Neuron 6.2]->[nrngui], Change to model directory (from NEURON main menu select [File] -> [working dir]), and then load the load "mosinit.hoc" hoc file from NEURON menubar [File]->[load hoc] MAC OS X: --------- Drag and drop the HOF folder onto the mknrndll icon. Drag and drop the mosinit.hoc file onto the nrngui icon. Linux/Unix: ----------- Compile the mod files by cd'ing to the extracted folder, HOF, and type nrnivmodl nrngui mosinit.hoc Once the simulation interface has started: ------------------------------------------ From [RunControl], press [Init&Run] to show simulation results. You should see a figure appear that looks like: which contains similar data as was used to create figure 2d: Note: You can use gap_r function to change gap junction resistance of each neuron pair gap_r() will show its usage. Set_ST to adjust stimulation interval and strength Set_ST() will show its usage.