NEURON { POINT_PROCESS GABAB1 } :** comments : Simple synaptic mechanism derived for first order kinetics of : binding of transmitter to postsynaptic receptors. : : GABA SYNAPSE (GABA-B receptors) : : Parameters estimated from patch clamp recordings of GABAB PSP's in : rat hippocampal slices (Otis et al, J. Physiol. 463: 391-407, 1993) : and sharp electrode recordings in hippocampal pyramidal cells : (Solis & Nicoll, J. Neurosci. 12: 3466-3472, 1992). : : To account for the time course of the GABAB IPSP with a first order : kinetics, it is assumed that the transmitter stays for 150 ms in the : synaptic cleft. This is very unrealistic, but it provides reasonable : summation of PSP's. : : A. Destexhe , The Salk Institute, May 1993. :** parameters PARAMETER { Cdur = 150 (ms) : transmitter duration (rising phase) Alpha = 0.01 (/ms mM) : forward (binding) rate Beta = 0.005 (/ms) : backward (unbinding) rate Erev = -95 (mV) : reversal potential (potassium) Deadtime = 1 (ms) : mimimum time between release events GMAX = 1 (umho) : maximum conductance DELAY = 0 (ms) : axonal delay } : should change delay to 50 ms!!!!!!!!!!!!!!!! INCLUDE "sns.inc" :* >>>> GABALOW - a GABAA<<<<