TITLE Cerebellum Golgi Cell Model COMMENT KCa channel Author: E.DAngelo, T.Nieus, A. Fontana Last revised: 8.5.2000 ENDCOMMENT NEURON { SUFFIX Golgi_BK USEION k READ ek WRITE ik USEION ca READ cai RANGE gkbar, ik, g RANGE Aalpha_c, Balpha_c, Kalpha_c, alpha_c, beta_c RANGE Abeta_c, Bbeta_c, Kbeta_c RANGE c_inf, tau_c, c, tcorr } UNITS { (mA) = (milliamp) (mV) = (millivolt) (molar) = (1/liter) (mM) = (millimolar) } PARAMETER { Aalpha_c = 7 (/ms) Balpha_c = 1.5e-3 (mM) Kalpha_c = -11.765 (mV) Abeta_c = 1 (/ms) Bbeta_c = 0.15e-3 (mM) Kbeta_c = -11.765 (mV) v (mV) cai (mM) gkbar= 0.003 (mho/cm2) ek (mV) celsius (degC) Q10 = 3 (1) } STATE { c } ASSIGNED { ik (mA/cm2) ica (mA/cm2) c_inf tau_c (ms) g (mho/cm2) alpha_c (/ms) beta_c (/ms) tcorr (1) } INITIAL { rate(v) c = c_inf } BREAKPOINT { SOLVE states METHOD derivimplicit g = gkbar*c ik = g*(v - ek) alpha_c = alp_c(v) beta_c = bet_c(v) } DERIVATIVE states { rate(v) c' =(c_inf - c)/tau_c } FUNCTION alp_c(v(mV))(/ms) { tcorr = Q10^((celsius-30(degC))/10(degC)) alp_c = tcorr*Aalpha_c/(1+(Balpha_c*exp(v/Kalpha_c)/cai)) } FUNCTION bet_c(v(mV))(/ms) { tcorr = Q10^((celsius-30(degC))/10(degC)) bet_c = tcorr*Abeta_c/(1+cai/(Bbeta_c*exp(v/Kbeta_c))) } PROCEDURE rate(v (mV)) {LOCAL a_c, b_c a_c = alp_c(v) b_c = bet_c(v) tau_c = 1/(a_c + b_c) c_inf = a_c/(a_c + b_c) }