This is the readme for the models associated with the paper: Sanjay M, Neymotin SA, Krothapalli SB (2015) Impaired dendritic inhibition leads to epileptic activity in a computer model of CA3. Hippocampus 25:1336-50 This simulation was tested/developed on LINUX systems, but may run on Microsoft Windows or Mac OS. To run, you will need the NEURON simulator (available at http://www.neuron.yale.edu) compiled with python enabled. The code ran with NEURON v7.2. Some problems have been noted with NEURON v7.4 and fixes are under development to allow the code to run with this newer version of NEURON. Unzip the contents of the zip file to a new directory. compile the mod files from the command line with: nrnivmodl *.mod That will produce an architecture-dependent folder with a script called special. On 64 bit systems the folder is x86_64. To run the simulation from the command line: ./x86_64/special -python mosinit.py then NEURON will start with the python interpreter and load the mechanisms and simulation. Next, the network and inputs will be setup. Then the simulation will be run for 5 seconds of simulation time. The simulation duration is modifiable via the h.tstop parameter in params.py. Note that setup of the network may take 10-30 seconds, depending on your processor speed and amount of RAM. Once the simulation has run, two graphs will be displayed, showing local field potential and individual cell responses and raster plot. The spike raster is arranged with y-axis as cell identifier and x-axis as time in milliseconds. The y-axis is further arranged in order of cell-types (red=pyramidal, green=basket, blue=OLM). For questions email: msanjaycmc at gmail dot com.