Model files from the paper:

Zylbertal et al., "Synchronous infra-slow bursting in the mouse
accessory olfactory bulb emerge from interplay between intrinsic
neuronal dynamics and network connectivity", J Neurosci (2017)
The file reproduces the protocol used
in Fig. 8 of the article by calling the modules

Questions on how to use this model should be directed to
asaph.zylbertal at


Infra-slow rhythmic neuronal activity with very long (> 10 s) period
duration was described in many brain areas but little is known about
the role of this activity and the mechanisms that produce it. Here we
combine experimental and computational methods to show that
synchronous infra-slow bursting activity in mitral cells of the mouse
accessory olfactory bulb (AOB) emerges from interplay between
intracellular dynamics and network connectivity. In this novel
mechanism, slow intracellular Na+ dynamics endow AOB mitral cells with
a weak tendency to burst, which is further enhanced and stabilized by
chemical and electrical synapses between them. Combined with the
unique topology of the AOB network, infra-slow bursting enables
integration and binding of multiple chemosensory stimuli over
prolonged time scale.

The example protocol simulates a two-glomeruli network (15-cell and
13-cell glomeruli) with a single shared cell. Although each glomerulus
is stimulated at a different time point, the activity of the entire
population becomes synchronous (see paper Fig. 8)

Example use:

Extract the archive, run nrnivmodl in the channels directory
(linux/unix) or mknrndll (mswin or mac os x) (see
for more help) to compile the channels, and run the file After a while, it will start plotting
the membrane potential of two cells, one from each glomerulus. The
completion of the simulation typically takes a few hours (see image