This is the README for the model associated with the paper: Canavier CC. (1999). Sodium dynamics underlying burst firing and putative mechanisms for the regulation of the firing pattern in midbrain dopamine neurons: a computational approach. J Comput Neurosci. 6:49-69 These model files were created by Dr Canavier. This example (after reaching steady oscillation) produces trajectories corresponding to Figure 5 A2. and Figure 6. The out.gif file shows the time plots generated by the example: Usage: Simply auto-launch from ModelDB or compile the mod files under MSWIN: ----- Use mknrndll (change directory to the one expanded from the archive and click "make nrnmech.dll"). Then run by double clicking the mosinit.hoc file in a windows explorer. MAC OS X -------- Drag and drop the expanded folder from this archive onto the mknrndll icon. Drag and drop the mosinit.hoc file onto the nrngui icon. Linux/Unix ---------- Change directory to the expanded folder and type these two lines: nrnivmodl nrngui mosinit.hoc Once the simulation is started ------------------------------ Press the init & run button to generate the above figure.