ÐÏà¡±á>þÿ <>þÿÿÿ;ÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿì¥Á€ð¿EbjbjëÈëÈ.‰¢‰¢E ÿÿÿÿÿÿ·˜˜ÜÜÜÜÜÿÿÿÿðððð$ðåt(((((dffffff$Y!¢û#LŠÜŠÜÜ((ÛŸwwwîÜ(Ü(dwdwwV$@è(ÿÿÿÿÌg<ÞþÉðñdPµ0åpxG$ñFG$èG$ÜèhwŠŠ7@åÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿG$˜ ¢:Author: Marco Pirini July 7th, 2009 Basics: the model has been created in a Matlab-Simulink environment; the model has been divided in 3, functionally non re-entrant, modules: the STNGPE one, the GPi one and the Thalamic one (possibility to re-use some simulation results from the upstream modules without the need to re-simulate the entire model ( reduced computation time & more control). The flow to simulate is: 1 launch launch_sysGPESTN1.m upload IC, parameters, additional currents, DBS currents if needed, etc launch the STNGPE module (GPESTN1.mdl – in this .mdl you will see the architecture used by Rubin and Terman as arised from a private communication with them) save results in a .mat file for the STNGPE simulation; ALTERNATIVELY: 1 launch launch_sysGPESTN1_GPEDBS.m to simulate DBS on GPe target if needed. The steps performed by this script are the same as by launch_sysGPESTN1.m. Remember: when asked, choose the GPESTN1_GPEDBS.mdl. 2 launch launch_sysGPI_mod.m upload IC, parameters, additional currents, DBS currents if needed, etc launch the GPI module (GPI1.mdl) save results in a .mat file for the GPI simulation; 3 launch launch_sysTAL_mod.m upload IC, parameters, additional currents, the cortical input, etc launch the TAL module (TAL8.mdl) analyze the results (thalamic spike sorting and classification) save results in a .mat file for the TAL simulation; Alternatively, once simulated all the possible (of interest) sets of parameters and conditions for the SNTGPe and the GPi modules (different conditions (norm, park, DBS on the 3 targets), different values of the ggpe( gpi conductance, different values of the Istriatum( Gpi, different DBS frequencies...) it’s possible to perform in a single step the simulation of the final thalamic module for all of the set of parameters (and for several realisations of the cortical input sequence to thalamus). You could do this by launching CN_launch_CN_analyze_TAL2.m that , in turn, recalls CN_analyze_tal2.m. Other files data_STN.m, data_GPe.m, data_GPi.m, data_TAL.m, data_synapses.m: sets of parameters for populations and synapses; in_val.mat: some sets of Initial conditions; sp_rev_thresh.m: thalamic spikes identification spike_contr.m: thalamic spike classification CN_calculate_sm.m: scripts that calculate a Poisson realization of the cortical input sequence to thalamus. 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