NEURON mod files from the paper:

Altered architecture and functional consequences of the mesolimbic
dopamine system in cannabis dependence.

Saturnino Spiga, Alessandra Lintas, Michele Migliore and Marco Diana
Addiction Biology, in press, 2010.

The simulation files control.hoc and after-withdrawal.hoc generate the
first 4 sec of the simulations in Fig. 7b top and bottom of the paper,
respectively.  They reproduce the simulations shown in the
supplementary movie.  In the figure is plotted the range 5<t<10
sec from 15 sec long simulations.

Questions on how to use this model should be directed to

Example Usage:

Auto-launch from ModelDB or download and extract the archive, compile
the mod files and start with either double clicking the mosinit.hoc
file (windows), drag and dropping the mosinit.hoc file on the nrngui
icon (mac OS X), or typing "nrngui mosinit.hoc" on the command line

Once the simulation is started pressing the "control" button should
result in the following graph similar to figure Fig. 7b top:


Note if the above graph is resized it looks more like the paper fig.:


20111122 Updated for NEURON 7.2: the MCellRan4 seeds were set < 2^32.