COMMENT ----------------------------------------------------------------------------- from ModelDB: Uebachs M, Opitz T, Royeck M, Dickhof G, Horstmann MT, Isom LL, Beck H (2010) Efficacy Loss of the Anticonvulsant Carbamazepine in Mice Lacking Sodium Channel beta Subunits via Paradoxical Effects on Persistent Sodium Currents. J Neurosci 30:8489-501 ----------------------------------------------------------------------------- ENDCOMMENT TITLE nap NEURON { SUFFIX nap USEION na READ ena WRITE ina RANGE gbar, thegna, sh, scalerate GLOBAL minf, mtau :, hinf, mtau, htau } PARAMETER { gbar = .0052085 (mho/cm2) sh = 0 (mV) eNa = 55 (mV) scalerate = 1 (ms) ena (mV) celsius (degC) v (mV) } UNITS { (mA) = (milliamp) (mV) = (millivolt) (pS) = (picosiemens) (um) = (micron) } ASSIGNED { ina (mA/cm2) thegna (mho/cm2) minf mtau (ms) } STATE { m } UNITSOFF BREAKPOINT { SOLVE states METHOD cnexp thegna =gbar*m ina = thegna * (v - eNa) } INITIAL { mtau = scalerate minf = (1/(1+exp(-(v+52.3-sh)/6.8))) m=minf } DERIVATIVE states { mtau = scalerate minf = (1/(1+exp(-(v+52.3-sh)/6.8))) m' = (minf-m)/mtau } UNITSON