/* Created by Language version: 6.0.2 */
/* NOT VECTORIZED */
#include <stdio.h>
#include <math.h>
#include "scoplib.h"
#undef PI
 
#include "md1redef.h"
#include "section.h"
#include "nrnoc_ml.h"
#include "md2redef.h"

#if METHOD3
extern int _method3;
#endif

#undef exp
#define exp hoc_Exp
extern double hoc_Exp();
 	/*SUPPRESS 761*/
	/*SUPPRESS 762*/
	/*SUPPRESS 763*/
	/*SUPPRESS 765*/
	 extern double *getarg();
 static double *_p; static Datum *_ppvar;
 
#define delta_t dt
#define Alpha _p[0]
#define Beta _p[1]
#define e _p[2]
#define iNMDA _p[3]
#define g _p[4]
#define gmax _p[5]
#define Ron _p[6]
#define Roff _p[7]
#define Rinf _p[8]
#define Rtau _p[9]
#define synon _p[10]
#define B _p[11]
#define DRon _p[12]
#define DRoff _p[13]
#define _g _p[14]
#define _tsav _p[15]
#define _nd_area  *_ppvar[0].pval
 
#if MAC
#if !defined(v)
#define v _mlhv
#endif
#if !defined(h)
#define h _mlhh
#endif
#endif
 static int hoc_nrnpointerindex =  -1;
 /* external NEURON variables */
 extern double dt;
 extern double t;
 /* declaration of user functions */
 static double _hoc_mgblock();
 static int _mechtype;
extern int nrn_get_mechtype();
 extern Prop* nrn_point_prop_;
 static int _pointtype;
 static void* _hoc_create_pnt(_ho) Object* _ho; { void* create_point_process();
 return create_point_process(_pointtype, _ho);
}
 static void _hoc_destroy_pnt();
 static double _hoc_loc_pnt(_vptr) void* _vptr; {double loc_point_process();
 return loc_point_process(_pointtype, _vptr);
}
 static double _hoc_has_loc(_vptr) void* _vptr; {double has_loc_point();
 return has_loc_point(_vptr);
}
 static double _hoc_get_loc_pnt(_vptr)void* _vptr; {
 double get_loc_point_process(); return (get_loc_point_process(_vptr));
}
 static _hoc_setdata(_vptr) void* _vptr; { Prop* _prop;
 _prop = ((Point_process*)_vptr)->_prop;
 _p = _prop->param; _ppvar = _prop->dparam;
 }
 /* connect user functions to hoc names */
 static IntFunc hoc_intfunc[] = {
 0,0
};
 static struct Member_func {
	char* _name; double (*_member)();} _member_func[] = {
 "loc", _hoc_loc_pnt,
 "has_loc", _hoc_has_loc,
 "get_loc", _hoc_get_loc_pnt,
 "mgblock", _hoc_mgblock,
 0, 0
};
#define _f_mgblock _f_mgblock_NMDAb
#define mgblock mgblock_NMDAb
 extern double _f_mgblock();
 extern double mgblock();
 /* declare global and static user variables */
#define Cmax Cmax_NMDAb
 double Cmax = 1;
#define Cdur Cdur_NMDAb
 double Cdur = 1.1;
#define mg mg_NMDAb
 double mg = 1;
#define usetable usetable_NMDAb
 double usetable = 1;
 /* some parameters have upper and lower limits */
 static HocParmLimits _hoc_parm_limits[] = {
 "usetable_NMDAb", 0, 1,
 0,0,0
};
 static HocParmUnits _hoc_parm_units[] = {
 "Cmax_NMDAb", "mM",
 "Cdur_NMDAb", "ms",
 "mg_NMDAb", "mM",
 "Alpha", "/ms",
 "Beta", "/ms",
 "e", "mV",
 "iNMDA", "nA",
 "g", "umho",
 0,0
};
 static double Roff0 = 0;
 static double Ron0 = 0;
 static double v = 0;
 /* connect global user variables to hoc */
 static DoubScal hoc_scdoub[] = {
 "Cmax_NMDAb", &Cmax,
 "Cdur_NMDAb", &Cdur,
 "mg_NMDAb", &mg,
 "usetable_NMDAb", &usetable,
 0,0
};
 static DoubVec hoc_vdoub[] = {
 0,0,0
};
 static double _sav_indep;
 static nrn_alloc(), nrn_init(), nrn_state();
 static nrn_cur(), nrn_jacob();
 static void _hoc_destroy_pnt(_vptr) void* _vptr; {
   destroy_point_process(_vptr);
}
 
static int _ode_count(), _ode_map(), _ode_spec(), _ode_matsol();
extern int nrn_cvode_;
 
#define _cvode_ieq _ppvar[3]._i
 /* connect range variables in _p that hoc is supposed to know about */
 static char *_mechanism[] = {
 "6.0.2",
"NMDAb",
 "Alpha",
 "Beta",
 "e",
 0,
 "iNMDA",
 "g",
 "gmax",
 0,
 "Ron",
 "Roff",
 0,
 0};
 
static nrn_alloc(_prop)
	Prop *_prop;
{
	Prop *prop_ion, *need_memb();
	double *_p; Datum *_ppvar;
  if (nrn_point_prop_) {
	_p = nrn_point_prop_->param;
	_ppvar = nrn_point_prop_->dparam;
 }else{
 	_p = nrn_prop_data_alloc(_mechtype, 16);
 	/*initialize range parameters*/
 	Alpha = 10;
 	Beta = 0.0125;
 	e = 0;
  }
 	_prop->param = _p;
 	_prop->param_size = 16;
  if (!nrn_point_prop_) {
 	_ppvar = nrn_prop_datum_alloc(_mechtype, 4);
  }
 	_prop->dparam = _ppvar;
 	/*connect ionic variables to this model*/
 
}
 static _initlists();
  /* some states have an absolute tolerance */
 static Symbol** _atollist;
 static HocStateTolerance _hoc_state_tol[] = {
 0,0
};
 
#define _tqitem &(_ppvar[2]._pvoid)
 static _net_receive();
 typedef (*_Pfrv)();
 extern _Pfrv* pnt_receive;
 extern short* pnt_receive_size;
 _NMDAb_reg() {
	int _vectorized = 0;
  _initlists();
 	_pointtype = point_register_mech(_mechanism,
	 nrn_alloc,nrn_cur, nrn_jacob, nrn_state, nrn_init,
	 hoc_nrnpointerindex,
	 _hoc_create_pnt, _hoc_destroy_pnt, _member_func,
	 _vectorized);
 _mechtype = nrn_get_mechtype(_mechanism[1]);
  hoc_register_dparam_size(_mechtype, 4);
 	hoc_register_cvode(_mechtype, _ode_count, _ode_map, _ode_spec, _ode_matsol);
 	hoc_register_tolerance(_mechtype, _hoc_state_tol, &_atollist);
 pnt_receive[_mechtype] = _net_receive;
 pnt_receive_size[_mechtype] = 5;
 	hoc_register_var(hoc_scdoub, hoc_vdoub, hoc_intfunc);
 	ivoc_help("help ?1 NMDAb /home/jg/ModelosNeuron/ProgramsNeuronCA1_JG/CleanVersion_CA1_JG_15Mar09/mechanism/x86_64/NMDAb.mod\n");
 hoc_register_limits(_mechtype, _hoc_parm_limits);
 hoc_register_units(_mechtype, _hoc_parm_units);
 }
 static double *_t_mgblock;
static int _reset;
static char *modelname = "simple NMDA receptors";

static int error;
static int _ninits = 0;
static int _match_recurse=1;
static _modl_cleanup(){ _match_recurse=1;}
 
static int _ode_spec1(), _ode_matsol1();
 extern int state_discon_flag_;
 static _check_mgblock();
 static double _n_mgblock();
 static int _slist1[2], _dlist1[2];
 static int release();
 
/*CVODE*/
 static int _ode_spec1 () {_reset=0;
 {
   DRon = ( synon * Rinf - Ron ) / Rtau ;
   DRoff = - Beta * Roff ;
   }
 return _reset;
}
 static int _ode_matsol1() {
 DRon = DRon  / (1. - dt*( ( ( ( - 1.0 ) ) ) / Rtau )) ;
 DRoff = DRoff  / (1. - dt*( (- Beta)*(1.0) )) ;
}
 /*END CVODE*/
 static int release () {_reset=0;
 {
    Ron = Ron + (1. - exp(dt*(( ( ( - 1.0 ) ) ) / Rtau)))*(- ( ( ( (synon)*(Rinf) ) ) / Rtau ) / ( ( ( ( - 1.0) ) ) / Rtau ) - Ron) ;
    Roff = Roff + (1. - exp(dt*((- Beta)*(1.0))))*(- ( 0.0 ) / ( (- Beta)*(1.0) ) - Roff) ;
   }
  return 0;
}
 static double _mfac_mgblock, _tmin_mgblock;
 static _check_mgblock() {
  static int _maktable=1; int _i, _j, _ix = 0;
  double _xi, _tmax;
  static double _sav_mg;
  if (!usetable) {return;}
  if (_sav_mg != mg) { _maktable = 1;}
  if (_maktable) { double _x, _dx; _maktable=0;
   _tmin_mgblock =  - 140.0 ;
   _tmax =  80.0 ;
   _dx = (_tmax - _tmin_mgblock)/1000.; _mfac_mgblock = 1./_dx;
   for (_i=0, _x=_tmin_mgblock; _i < 1001; _x += _dx, _i++) {
    _t_mgblock[_i] = _f_mgblock(_x);
   }
   _sav_mg = mg;
  }
 }

 double mgblock(_lv) double _lv;{ _check_mgblock();
 return _n_mgblock(_lv);
 }

 static double _n_mgblock(_lv) double _lv;{ int _i, _j;
 double _xi, _theta;
 if (!usetable) {
 return _f_mgblock(_lv); 
}
 _xi = _mfac_mgblock * (_lv - _tmin_mgblock);
 _i = (int) _xi;
 if (_xi <= 0.) {
 return _t_mgblock[0];
 }
 if (_i >= 1000) {
 return _t_mgblock[1000];
 }
 return _t_mgblock[_i] + (_xi - (double)_i)*(_t_mgblock[_i+1] - _t_mgblock[_i]);
 }

 
double _f_mgblock (  _lv )  
	double _lv ;
 {
   double _lmgblock;
 _lmgblock = 1.0 / ( 1.0 + exp ( 0.062 * - _lv ) * ( mg / 3.57 ) ) ;
   
return _lmgblock;
 }
 static double _hoc_mgblock(_vptr) void* _vptr; {
 double _r;
 	_hoc_setdata(_vptr);
  _r =  mgblock (  *getarg(1) ) ;
 return(_r);
}
 
static _net_receive (_pnt, _args, _lflag) Point_process* _pnt; double* _args; double _lflag; 
{ _p = _pnt->_prop->param; _ppvar = _pnt->_prop->dparam;
  if (_tsav > t){ extern char* hoc_object_name(); hoc_execerror(hoc_object_name(_pnt->ob), ":Event arrived out of order. Must call ParallelContext.set_maxstep AFTER assigning minimum NetCon.delay");}
 _tsav = t;   if (_lflag == 1. ) {*(_tqitem) = 0;}
 {
   if ( _lflag  == 0.0 ) {
     _args[2] = _args[2] + 1.0 ;
     if (  ! _args[1] ) {
       _args[3] = _args[3] * exp ( - Beta * ( t - _args[4] ) ) ;
       _args[4] = t ;
       _args[1] = 1.0 ;
       synon = synon + _args[0] ;
       state_discontinuity ( _cvode_ieq + 0, & Ron , Ron + _args[3] ) ;
       state_discontinuity ( _cvode_ieq + 1, & Roff , Roff - _args[3] ) ;
       }
     net_send ( _tqitem, _args, _pnt, Cdur , _args[2] ) ;
     }
   if ( _lflag  == _args[2] ) {
     _args[3] = _args[0] * Rinf + ( _args[3] - _args[0] * Rinf ) * exp ( - ( t - _args[4] ) / Rtau ) ;
     _args[4] = t ;
     synon = synon - _args[0] ;
     state_discontinuity ( _cvode_ieq + 0, & Ron , Ron - _args[3] ) ;
     state_discontinuity ( _cvode_ieq + 1, & Roff , Roff + _args[3] ) ;
     _args[1] = 0.0 ;
     }
   gmax = _args[0] ;
   } }
 
static int _ode_count(_type) int _type;{ return 2;}
 
static int _ode_spec(_nd, _pp, _ppd) Node* _nd; double* _pp; Datum* _ppd; {
	_p = _pp; _ppvar = _ppd; v = NODEV(_nd);
  _ode_spec1();
 }
 
static int _ode_map(_ieq, _pv, _pvdot, _pp, _ppd, _atol, _type) int _ieq, _type; double** _pv, **_pvdot, *_pp, *_atol; Datum* _ppd; {
	int _i; _p = _pp; _ppvar = _ppd;
	_cvode_ieq = _ieq;
	for (_i=0; _i < 2; ++_i) {
		_pv[_i] = _pp + _slist1[_i];  _pvdot[_i] = _pp + _dlist1[_i];
		_cvode_abstol(_atollist, _atol, _i);
	}
 }
 
static int _ode_matsol(_nd, _pp, _ppd) Node* _nd; double* _pp; Datum* _ppd; {
	_p = _pp; _ppvar = _ppd; v = NODEV(_nd);
 _ode_matsol1();
 }

static initmodel() {
  int _i; double _save;_ninits++;
 _save = t;
 t = 0.0;
{
  Roff = Roff0;
  Ron = Ron0;
 {
   Rinf = Cmax * Alpha / ( Cmax * Alpha + Beta ) ;
   Rtau = 1.0 / ( Cmax * Alpha + Beta ) ;
   synon = 0.0 ;
   }
  _sav_indep = t; t = _save;

}
}

static nrn_init(_ml, _type) _Memb_list* _ml; int _type;{
Node *_nd; double _v; int* _ni; int _iml, _cntml;
#if CACHEVEC
    _ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
 _p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
 _tsav = -1e20;
#if CACHEVEC
  if (use_cachevec) {
    _v = VEC_V(_ni[_iml]);
  }else
#endif
  {
    _nd = _ml->_nodelist[_iml];
    _v = NODEV(_nd);
  }
 v = _v;
 initmodel();
}}

static double _nrn_current(_v) double _v;{double _current=0.;v=_v;{ {
   B = mgblock (  v ) ;
   g = ( Ron + Roff ) * 1.0 * B ;
   iNMDA = g * ( v - e ) ;
   }
 _current += iNMDA;

} return _current;
}

static nrn_cur(_ml, _type) _Memb_list* _ml; int _type;{
Node *_nd; int* _ni; double _rhs, _v; int _iml, _cntml;
#if CACHEVEC
    _ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
 _p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if CACHEVEC
  if (use_cachevec) {
    _v = VEC_V(_ni[_iml]);
  }else
#endif
  {
    _nd = _ml->_nodelist[_iml];
    _v = NODEV(_nd);
  }
 _g = _nrn_current(_v + .001);
 	{ state_discon_flag_ = 1; _rhs = _nrn_current(_v); state_discon_flag_ = 0;
 	}
 _g = (_g - _rhs)/.001;
 _g *=  1.e2/(_nd_area);
 _rhs *= 1.e2/(_nd_area);
#if CACHEVEC
  if (use_cachevec) {
	VEC_RHS(_ni[_iml]) -= _rhs;
  }else
#endif
  {
	NODERHS(_nd) -= _rhs;
  }
 
}}

static nrn_jacob(_ml, _type) _Memb_list* _ml; int _type;{
Node *_nd; int* _ni; int _iml, _cntml;
#if CACHEVEC
    _ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
 _p = _ml->_data[_iml];
#if CACHEVEC
  if (use_cachevec) {
	VEC_D(_ni[_iml]) += _g;
  }else
#endif
  {
     _nd = _ml->_nodelist[_iml];
	NODED(_nd) += _g;
  }
 
}}

static nrn_state(_ml, _type) _Memb_list* _ml; int _type;{
 double _break, _save;
Node *_nd; double _v; int* _ni; int _iml, _cntml;
#if CACHEVEC
    _ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
 _p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
 _nd = _ml->_nodelist[_iml];
#if CACHEVEC
  if (use_cachevec) {
    _v = VEC_V(_ni[_iml]);
  }else
#endif
  {
    _nd = _ml->_nodelist[_iml];
    _v = NODEV(_nd);
  }
 _break = t + .5*dt; _save = t; delta_t = dt;
 v=_v;
{
 { {
 for (; t < _break; t += delta_t) {
 error =  release();
 if(error){fprintf(stderr,"at line 105 in file NMDAb.mod:\n	SOLVE release METHOD cnexp\n"); nrn_complain(_p); abort_run(error);}
 
}}
 t = _save;
 }}}

}

static terminal(){}

static _initlists() {
 int _i; static int _first = 1;
  if (!_first) return;
 _slist1[0] = &(Ron) - _p;  _dlist1[0] = &(DRon) - _p;
 _slist1[1] = &(Roff) - _p;  _dlist1[1] = &(DRoff) - _p;
   _t_mgblock = makevector(1001*sizeof(double));
_first = 0;
}