COMMENT T-type Ca channel ca.mod to lead to thalamic ca current inspired by destexhe and huguenrd Uses fixed eca instead of GHK eqn changed from (AS Oct0899) changed for use with Ri18 (B.Kampa 2005) changed the suffix for ease of implementation in (Delgado J.Y. ) ENDCOMMENT INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)} NEURON { SUFFIX cat USEION ca READ eca WRITE ica RANGE m, h, gca, gbar RANGE minf, hinf, mtau, htau, inactF, actF GLOBAL vshift,vmin,vmax, v12m, v12h, vwm, vwh, am, ah, vm1, vm2, vh1, vh2, wm1, wm2, wh1, wh2 } PARAMETER { gbar = 0.0008 (mho/cm2) : 0.12 mho/cm2 vshift = 0 (mV) : voltage shift (affects all) cao = 2.5 (mM) : external ca concentration cai (mM) v (mV) dt (ms) celsius (degC) vmin = -120 (mV) vmax = 100 (mV) v12m=50 (mV) v12h=78 (mV) vwm =7.4 (mV) vwh=5.0 (mV) am=3 (mV) ah=85 (mV) vm1=25 (mV) vm2=100 (mV) vh1=46 (mV) vh2=405 (mV) wm1=20 (mV) wm2=15 (mV) wh1=4 (mV) wh2=50 (mV) } UNITS { (mA) = (milliamp) (mV) = (millivolt) (pS) = (picosiemens) (um) = (micron) FARADAY = (faraday) (coulomb) R = (k-mole) (joule/degC) PI = (pi) (1) } ASSIGNED { ica (mA/cm2) gca (pS/um2) eca (mV) minf hinf mtau (ms) htau (ms) tadj } STATE { m h } INITIAL { trates(v+vshift) m = minf h = hinf } BREAKPOINT { SOLVE states gca = gbar*m*m*h ica = gca * (v - eca) } LOCAL mexp, hexp PROCEDURE states() { trates(v+vshift) m = m + mexp*(minf-m) h = h + hexp*(hinf-h) VERBATIM return 0; ENDVERBATIM } PROCEDURE trates(v) { LOCAL tinc TABLE minf, mexp, hinf, hexp DEPEND dt FROM vmin TO vmax WITH 199 rates(v): not consistently executed from here if usetable == 1 tinc = -dt mexp = 1 - exp(tinc/mtau) hexp = 1 - exp(tinc/htau) } PROCEDURE rates(v_) { LOCAL a, b minf = 1.0 / ( 1 + exp(-(v_+v12m)/vwm) ) hinf = 1.0 / ( 1 + exp((v_+v12h)/vwh) ) mtau = ( am + 1.0 / ( exp((v_+vm1)/wm1) + exp(-(v_+vm2)/wm2) ) ) htau = ( ah + 1.0 / ( exp((v_+vh1)/wh1) + exp(-(v_+vh2)/wh2) ) ) }