// For each band of gaba synapses, this function makes a file with the // stimulation train and shifts the activation time (by temporal_offset) // written by Yiota Poirazi, July 2001, poirazi@LNC.usc.edu double iary[1000] objref vary[1000], s_file, stimtmp, rpid stimtmp = new Vector() strdef shiftsyn_filename, syscmd, estr proc gaba_shift() { local synapses, temporal_offset, hertz, gmax_default, PID, lo, hi synapses = $1 // number of synapses in the band tstop = $2 // stimulation end time dt = $3 hertz = $4 // stimulation train frequency synch = $5 // synchronous or a synchronous stimulation of synapses perio = $6 // periodic or not periodic stimulation PID = $7 PID = abs(PID) // only positive random seeds used for spike train generation temporal_offset = $8 // shift stimulation time by temporal_offset // Make the desired activation pattern file and // Set GABA pointers to activation pattern sprint(shiftsyn_filename,"gaba_shiftsyn-%d-%.2f-%.2f-%.2f-%.2f-%.2f-%d-%.2f",\ synapses,tstop,dt,hertz,synch,perio,PID,temporal_offset) // filename sprint(syscmd,"newshiftsyn gaba_shiftsyn %d %g %g %g %g %g %d %g",\ synapses,tstop,dt,hertz,synch,perio,PID,temporal_offset) // use newshiftsyn to make // stimulation train system(syscmd) // Same as typing syscmd in DOS, execute above command print syscmd s_file = new File() s_file.ropen(shiftsyn_filename) // open the stimulation train file stimtmp.scanf(s_file) // read temporal stimulation pattern in a 1-d vector s_file.close() items = int(tstop/dt) // number of stimuli (firing patterns) for each synapse for i=0,synapses-1 { // printf(" -- synapse %d\n", i) vary[i] = new Vector(items) // for each synapse, save firing pattern in this vector // Put the firing patterns from stimtmp (1-d vector) to a 2-d vector for each synapse i for j=0,items-1 { vary[i].x[j]=stimtmp.x[i + j*synapses] } } // print "setpointer to each synapse" for s=0, synapses-1 { sprint(estr,"vary[%d].play(&iary[%d])", s,s) execute1(estr) // print estr sprint(estr,"setpointer gabaa[%d].pre, iary[%d]", s,s) execute1(estr) // print estr sprint(estr,"setpointer gabab[%d].pre, iary[%d]", s,s) execute1(estr) // print estr } sprint(econ.syscmd, "rm %s", shiftsyn_filename) // remove firing pattern file print econ.syscmd system(econ.syscmd) sprint(econ.syscmd, "rm ERROR*") // if an error file is generated, remove it as well print econ.syscmd // this is because newshiftsyn gives error messages system(econ.syscmd) // that don't affect the firing patterns generated // if errors do happen, NEURON crashes }