COMMENT Forti etal's (1997) AMPA synapse with two decay time constants based on the exp2syn.mod mechanism from the NEURON distribution The value of 0.002 for the fraction of Ca flowing at low membrane potentials is derived from the measurements of Spruston &al (1995) Forti & al. 1997 "Loose-patch recordings of single quanta at individual hippocampal synapses" Nature 388, 874-878 Spruston & al. 1995 "Dendritic glutamate receptor channels in rat hippocampal CA3 and CA1 neurons" J. Physiol. 482, 325-352 ENDCOMMENT NEURON { POINT_PROCESS AmpaSyn RANGE e, g, i, ica NONSPECIFIC_CURRENT i USEION ca READ cai,cao WRITE ica GLOBAL total, taurise, taufast, tauslow, taurise_exp, taufast_exp, tauslow_exp, afast, aslow, normfac, T_exp, fracca } INCLUDE "units.inc" PARAMETER { taurise_exp =.2 (ms) <1e-9,1e9> : rise taufast_exp = 0.61 (ms) <1e-9,1e9> : fast decay tauslow_exp = 2.55 (ms) <1e-9,1e9> : slow decay afast = 0.75 <0,1> e=0 (mV) fracca= 0.002 : fraction of current that is ca ions z = 2 celsius = 22 (degC) T_exp = 22 (degC) q10 = 3 } ASSIGNED { v (mV) i (nA) ica (nA) g (uS) aslow total (uS) cai (mM) cao (mM) taurise (ms) taufast (ms) tauslow (ms) normfac } BREAKPOINT { SOLVE state METHOD cnexp g = (B + C - A) i = g * (1-fracca) * (v - e) ica = g * fracca * ghkg(v,cai,cao,z) } INCLUDE "triexpsyn.inc" INCLUDE "ghk.inc"