TITLE Sodium transient current for RD Traub et al 2003, 2005 COMMENT Implemented by Maciej Lazarewicz 2003 (mlazarew@seas.upenn.edu) fastNashift init to 0 and removed from arg modification Tom Morse 3/8/2006 (for Traub et al 2005) Also further changed to match naf in tcr. ENDCOMMENT INDEPENDENT { t FROM 0 TO 1 WITH 1 (ms) } UNITS { (mV) = (millivolt) (mA) = (milliamp) } NEURON { SUFFIX naf_tcr USEION na READ ena WRITE ina RANGE gbar, ina,m, h, df, shift_mnaf, minf, mtau RANGE shift_hnaf, shift_mnaf_init, shift_mnaf_run, hinf, htau RANGE shift_hnaf_run } PARAMETER { shift_mnaf_init =-3 (mV) : these two variable names suggest where they came from shift_mnaf_run = -2.5 (mV) : in the fortran code shift_hnaf = -7.0 (mV) gbar = 0.0 (mho/cm2) v (mV) ena (mV) } ASSIGNED { shift_mnaf (mV) ina (mA/cm2) minf (1) hinf (1) mtau (ms) htau (ms) df (mV) } STATE { m h } BREAKPOINT { SOLVE states METHOD cnexp ina = gbar * m * m * m * h * ( v - ena ) df = v - ena } INITIAL { settables( v ) m = minf m = 0 h = hinf } DERIVATIVE states { settables( v ) m' = ( minf - m ) / mtau h' = ( hinf - h ) / htau } UNITSOFF PROCEDURE settables(v1(mV)) { TABLE minf, hinf, mtau, htau FROM -120 TO 40 WITH 641 shift_mnaf = shift_mnaf_init + shift_mnaf_run minf = 1 / ( 1 + exp( ( - ( v1 + shift_mnaf ) - 38 ) / 10 ) ) if( ( v1 + shift_mnaf ) < -30.0 ) { mtau = 0.025 + 0.14 * exp( ( ( v1 + shift_mnaf ) + 30 ) / 10 ) } else{ mtau = 0.02 + (0.145) * exp( ( - ( v1 + shift_mnaf ) - 30 ) / 10 ) } : hinf, and htau are shifted 3.5 mV comparing to the paper hinf = 1.0 / ( 1.0 + exp( ( v1 + shift_hnaf + 62.9 ) / 10.7 ) ) htau = 0.15 + 1.15 / ( 1.0 + exp( ( v1 + 37.0 ) / 15.0 ) ) } UNITSON