//============================================= // Granule Cells with Spines //============================================= load_file("nrngui.hoc") xopen("$(NEURONHOME)/lib/hoc/noload.hoc") // standard run tools load_file("GC_def.hoc") v_init = -70 tstop = 2500 celsius = 35 MUSCAR = 0 // 1: Muscarinic effect on; 0: OFF objref Gran Gran = new Granule(MUSCAR) load_file("GC_save.hoc") objref stim1, stim2, stim3, stim4 Gran.soma stim1 = new IClamp(0.5) Gran.soma stim2 = new IClamp(0.5) Gran.soma stim3 = new IClamp(0.5) Gran.soma stim4 = new IClamp(0.5) stim1.del = 0 // 500 stim1.dur = tstop stim1.amp = 0.0 // 0.0102/0.01 for ADP; 0.0105 for AHP | 0.0106/0.116 for CCH stim2.del = 500 stim2.dur = 50 // stim2.amp = 0.0 // stim3.del = 1000 stim3.dur = 600 // 500 for ADP stim3.amp = 0.03 // 0.103/0.115 for ADP; 0.118 for AHP; 0.1 for CCH stim4.del = 1800 stim4.dur = 50 stim4.amp = -0.0 // objref g1,g2,g3,g4,g5,g6,g7 proc fig1() { g1 = new Graph(0) addplot(g1, 0) g1.size(0,tstop,-80,50) g1.view(0,-80,tstop,130, 0,150,500,160) g1.addvar("Soma.V", "Gran.soma.v(0.5)", 3, 1, 0.8, 0.9, 2) //1: black; 2: red; 3: blue g6 = new Graph(0) addplot(g6, 0) g6.size(0,tstop,-80,50) g6.view(0,-80,tstop,130, 0,500,500,160) g6.addvar("Dend.V", "Gran.dend.v(0.5)", 2, 1, 0.8, 0.9, 2) g2 = new Graph(0) addplot(g2, 0) g2.size(0,tstop,0,0.5) g2.view(0,0,tstop,0.5, 0,700,500,130) g2.addvar("Dend.Ca", "Gran.dend.cai", 2, 2, 0.8, 0.9, 2) g7 = new Graph(0) addplot(g7, 0) g7.size(0,tstop,0,1) g7.view(0,0,tstop,1, 0,900,500,150) g7.addvar("IA.m", "Gran.dend.m_kamt", 5, 2, 0.8, 0.9, 2) g7.addvar("IA.h", "Gran.dend.h_kamt", 1, 2, 0.8, 0.9, 2) g3 = new Graph(0) addplot(g3, 0) g3.size(0,tstop,-0.05,0.05) g3.view(0,-0.05,tstop,0.1, 0,900,500,130) g3.addvar("IA", "Gran.dend.ik_kamt", 3, 2, 0.8, 0.9, 2) /* g4 = new Graph(0) addplot(g4, 0) g4.size(0,tstop,0,1) g4.view(0,0,tstop,1, 0,900,500,150) g4.addvar("Ican.m", "Gran.dend.m_Ican", 5, 2, 0.8, 0.9, 2) //1: black; 2: red; 3: blue g5 = new Graph(0) addplot(g5, 0) g5.size(0,tstop,0,2) g5.view(0,0,tstop,2, 0,450,500,130) g5.addvar("Soma.Ca", "Gran.soma.cai", 2, 2, 0.8, 0.9, 2) */ } fig1() run() save_data()