//====================================================================== // Specify parameters of the model //====================================================================== NTCE = 0 // When NTCE=0, full model is simulated with EPL (with granule cells) // When NTCE=1, glomerular model is simulated without granuel cells // Control ON/OFF of nicotinic and muscarinic effect NICOTIN = 0 // 0: nAChRs inactive; 1: nAChRs activated MUSCARIN = 0 // 0: mAChRs inactive; 1: mAChRs activated netseed = 2 // Random seed used for the Netstim object in generating random background inputs // This parameter varied from 0 to 11 in Fig. 12 of the paper seedU = 88 // Random seed for uniform distribution seedN = 100 // Random seed for normal (Gaussian) distribution Todor = 2000 // Start time of odor // Synaptic weights Wm2p = 1 // MC to PG weight Wm2g = 1 // MC to GC weight Wp2m = 8 // PG to MC weight Wg2m = 1 // GC to MC weight // Number of neurons nMit = 25 // 25 nPG = 25 // 25 nGran = 100 // 100 P = 0.3 // Connectivity probability between MCs and GCs LL = 500 // MC latral dend length in um // Specific inputs Km2p = 0.4 // Scaling factor between MC and PG input: Ipg=Km2p*Imc // i.e., Odor input intensity is scaled down from MCs to PGs // Peak conductance AMPAgmaxPG = 2e-3 // Maximal conductance for MC-PG synapses NMDAgmaxPG = 1e-3 // Maximal conductance for MC-PG synapses GABAAgmaxPG = 2e-3 // Maximal conductance for PG-MC synapses AMPAgmaxGC = 2e-3 // Maximal conductance for MC-GC synapses NMDAgmaxGC = 1e-3 // Maximal conductance for MC-GC synapses GABAAgmaxGC = 1.5e-3 // Maximal conductance for GC-MC synapses // Synaptic time constants tau1_AMPA = 1 // Riset time constant tau2_AMPA = 5.5 // Decay time constant tau1_NMDA = 52 // Rise time tau2_NMDA = 343 // Decay time tau1_GABA = 1.25 // Rise time tau2_GABA = 18 // Decay time AMPAalpha = 1/tau1_AMPA AMPAbeta = 1/tau2_AMPA NMDAalpha = 1/tau1_NMDA NMDAbeta = 1/tau2_NMDA GABAAalpha = 1/tau1_GABA GABAAbeta = 1/tau2_GABA // Reserval potentials AMPArev = 0 NMDArev = 0 GABAArev = -80 // Synapitc half-activation AMPAact = 0 // NMDAact = 0 // GABAAact = -40 // Synaptic gradeness AMPAsigma = 0.2 NMDAsigma = 0.2 GABAAsigma = 2