TITLE A slow Sodium current COMMENT Used in Role of a Striatal Slowly Inactivating Potassion Current in Short-term Facilitation of Corticostriatal Inputs" A computer Simulation Study" (Mahon et al. 2000) Implemented by Kevin M. Biddell kevin.biddell@gmail.com 7/17/06 NOTE: 1S=1mho Neuron wants the units in mhos not millisiemens, please note the conversion! ENDCOMMENT UNITS { (mA) = (milliamp) (mV) = (millivolt) } NEURON { SUFFIX NaSm USEION na WRITE ina RANGE gnasmbar, gnasm, minf, mtau } INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)} PARAMETER { ena = 40 (mV) gnasmbar= 0.00011 (mho/cm2) :0.11mS Etemp = 21 :delord correspondence 11/15/06 Vsm = -16.0 ksm = 9.4 tom = 637.8 Vtm = -33.5 ktm = 26.3 } STATE { m } ASSIGNED { v (mV) ina (mA/cm2) celsius (degC) minf mtau gnasm } BREAKPOINT { SOLVE states METHOD cnexp gnasm = gnasmbar*m ina = gnasm*(v - ena) } UNITSOFF INITIAL { rates(v) m= minf } DERIVATIVE states { :Computes states variable m at the current v and dt. rates(v) m' = ( minf - m ) / mtau } PROCEDURE rates(v) { :Computes rate and other constants at current v. Call once from HOC to initialize inf at resting v. LOCAL q10,tadj q10 = 2.5 tadj=q10^((celsius-Etemp)/10) minf=1/(1+exp(-(v-Vsm)/ksm)) mtau=tom/(exp(-(v-Vtm)/ktm)+exp((v-Vtm)/ktm))/tadj } UNITSON