celsius = 35 Rm = 28000 RmDend = Rm RmSoma = Rm RmAx = Rm Cm = 1 CmSoma = Cm CmAx = Cm CmDend = Cm RaAll = 150 RaSoma =150 RaAx = 50 Vrest =-65 forsec "axon" { insert pas e_pas=Vrest g_pas = 1/RmAx Ra=RaAx cm=CmAx } forsec "soma" { insert pas e_pas=Vrest g_pas = 1/RmSoma Ra=RaSoma cm=CmSoma } forsec "dendrite" { insert pas e_pas=Vrest g_pas = 1/RmDend Ra=RaAll cm=CmDend } forsec "user5" { insert pas e_pas=Vrest g_pas = 1/RmDend Ra=RaAll cm=CmDend } load_file("setnseg.hoc") access soma distance() gna = 0.025 AXONM = 5 gkdr = 0.01 KMULT = 0.03 KMULTP = 0.03 ghd = 0.00005 forsec "axon" { insert nax gbar_nax=gna*AXONM insert kdr gkdrbar_kdr=gkdr insert kap gkabar_kap=KMULTP } forsec "soma" { insert hd ghdbar_hd=ghd vhalfl_hd=-73 insert na3 gbar_na3=gna insert kdr gkdrbar_kdr=gkdr insert kap gkabar_kap=KMULTP } for i = 0, numbasal - 1 dendrite[i] { insert hd ghdbar_hd=ghd vhalfl_hd=-73 insert na3 gbar_na3=gna insert kdr gkdrbar_kdr=gkdr insert kap gkabar_kap=0 insert kad gkabar_kad=0 for(x) if(x > 0 && x < 1) { xdist = distance(x) ghdbar_hd(x) = ghd*(1+3*xdist/100) if(xdist > 100){ vhalfl_hd=-81 gkabar_kad(x) = KMULT*(1+xdist/100) } else { vhalfl_hd=-73 gkabar_kap(x) = KMULTP*(1+xdist/100) } } } forsec "apical_dendrite" { insert hd ghdbar_hd=ghd insert na3 gbar_na3=gna insert kdr gkdrbar_kdr=gkdr insert kap gkabar_kap=0 insert kad gkabar_kad=0 for(x) if(x > 0 && x < 1) { xdist = distance(x) ghdbar_hd(x) = ghd*(1+3*xdist/100) if(xdist > 100) { vhalfl_hd=-81 gkabar_kad(x) = KMULT*(1+xdist/100) } else { vhalfl_hd=-73 gkabar_kap(x) = KMULTP*(1+xdist/100) } } } forsec "user5" { insert hd ghdbar_hd=ghd insert na3 gbar_na3=gna insert kdr gkdrbar_kdr=gkdr insert kap gkabar_kap=0 insert kad gkabar_kad=0 for(x) if(x > 0 && x < 1) { xdist = distance(x) ghdbar_hd(x) = ghd*(1+3*xdist/100) if(xdist > 100) { vhalfl_hd=-81 gkabar_kad(x) = KMULT*(1+xdist/100) } else { vhalfl_hd=-73 gkabar_kap(x) = KMULTP*(1+xdist/100) } } } proc init() { t = 0 forall { v = Vrest if(ismembrane("nax") || ismembrane("na3")) { ena=55 } if(ismembrane("kdr") || ismembrane("kap") || ismembrane("kad")) { ek=-90 } if(ismembrane("hd")) { ehd_hd=-30 } } finitialize(Vrest) fcurrent() forall { for(x) { if(ismembrane("na3") || ismembrane("nax")) { e_pas(x)=v(x)+(ina(x)+ik(x))/g_pas(x) } if(ismembrane("hd")) { e_pas(x)=e_pas(x)+i_hd(x)/g_pas(x) } } } }