/* Dentage Gyrus Granule Cell model associated with the papers: J. Tejada, G.M. Arisi, N. Garcia-Cairasco, A.C. Roque, Morphological alterations in newly born dentate gyrus granule cells that emerge after status epilepticus contribute to make them less excitable, PLoS ONE. 7 (2012) e40726. doi:10.1371/journal.pone.0040726. J. Tejada, N. Garcia-Cairasco, A.C. Roque, Combined role of seizure-induced dendritic morphology alterations and spine loss in newborn granule cells with mossy fiber sprouting on the hyperexcitability of a computer model of the dentate gyrus, PLoS Comput. Biol. 10 (2014) e1003601. doi:10.1371/journal.pcbi.1003601. julian.tejada@gmail.com - 2014 */ //Defining granule cell begintemplate GranuleCell5 // Original name on neuroMorpho.org n05-cont02-sl1.CNG.swc ndend1=9 public pre_list, connect_pre, subsets, is_art, is_connected public vbc2gc, vmc2gc, vhc2gc, vgc2bc, vbc2bc, vmc2bc, vhc2bc, vgc2mc, vbc2mc, vmc2mc, vhc2mc, vgc2hc, vmc2hc public soma, dend public all, gcldend, /*pdend,*/ mdend, ddend nst=10 objectvar stim[nst] double stimdur[nst], stimdel[nst], stimamp[nst] public stim, stimdur, stimamp, stimdel create soma, dend[ndend1] objref syn, pre_list proc init() { pre_list = new List() subsets() gctemp() synapse() } objref all, gcldend, /*pdend,*/ mdend, ddend proc subsets(){ local i objref all, gcldend, /*pdend,*/ mdend, ddend all = new SectionList() soma all.append() for i=0, 8 dend[i] all.append() gcldend = new SectionList() dend[0] gcldend.append() // pdend = new SectionList() // for i=1, 4 dend[i] pdend.append() mdend = new SectionList() for i=1, 2 dend[i] mdend.append() ddend = new SectionList() // dend[3] ddend.append() for i=3, 8 dend[i] ddend.append() // for i=9, 10 dend[i] ddend.append() } proc gctemp() { // soma {nseg=1 L=16.329 diam=11.165} // changed L & diam // // dend [0] {nseg=1 L=20.05632 diam=2.6} // dend [1] {nseg=1 L=80.78021 diam=1.6478} // dend [2] {nseg=1 L=10.61434 diam=1.1833} // dend [3] {nseg=1 L=25.82767 diam=1.0346} // dend [4] {nseg=1 L=30.89202 diam=0.7664} // dend [5] {nseg=1 L=43.53635 diam=0.9072} // dend [6] {nseg=1 L=37.46003 diam=0.9215} // dend [7] {nseg=1 L=85.47885 diam=0.5756} // dend [8] {nseg=1 L=121.54242 diam=0.6968} // dend [9] {nseg=1 L=78.91646 diam=0.6705} // dend [10] {nseg=1 L=97.50034 diam=0.7203} // dend [11] {nseg=1 L=19.96318 diam=0.8309} // dend [12] {nseg=1 L=125.23049 diam=0.5746} // dend [13] {nseg=1 L=117.23326 diam=0.6059} // dend [14] {nseg=1 L=31.96199 diam=0.6411} // dend [15] {nseg=1 L=45.48879 diam=0.6389} // dend [16] {nseg=1 L=22.50602 diam=0.5591} // dend [17] {nseg=1 L=37.40208 diam=0.6970} // dend [18] {nseg=1 L=20.88699 diam=0.6050} // dend [19] {nseg=1 L=10.10732 diam=0.5985} // for i = 1, 20 dend [i] {nseg=1 L=150 diam=3} // gcdend2 [0] {nseg=1 L=50 diam=3} // for i = 1, 3 gcdend2 [i] {nseg=1 L=150 diam=3} forsec all { insert ccanl catau_ccanl = 10 caiinf_ccanl = 0.000005 Ra=210 } soma {insert ichan2 //ildikos ichan gnatbar_ichan2=0.12 //original 0.030 to .055 gkfbar_ichan2=0.016 //original 0.015 gksbar_ichan2=0.006 insert borgka gkabar_borgka=0.012 insert nca // HAV-N- Ca channel gncabar_nca=0.002 // check to modify- original 0.004 insert lca glcabar_lca=0.005 insert cat gcatbar_cat=0.000037 insert gskch gskbar_gskch=0.001 insert cagk gkbar_cagk=0.0006 gl_ichan2 = 0.00004 cm=1 } forsec gcldend {insert ichan2 gnatbar_ichan2=0.018 //original 0.015 gkfbar_ichan2=0.004 gksbar_ichan2=0.006 insert nca // HAV-N- Ca channel gncabar_nca=0.003 // check to modify- original 0.004 insert lca glcabar_lca=0.0075 insert cat gcatbar_cat=0.000075 insert gskch gskbar_gskch=0.0004 insert cagk gkbar_cagk=0.0006 gl_ichan2 = 0.00004 cm=1} // forsec pdend {insert ichan2 // gnatbar_ichan2=0.013 // gkfbar_ichan2=0.004 // gksbar_ichan2=0.006 // insert nca // HAV-N- Ca channel // gncabar_nca=0.001 // check to modify- original 0.004 // insert lca // glcabar_lca=0.0075 // insert cat // gcatbar_cat=0.00025 // insert gskch // gskbar_gskch=0.0002 // insert cagk // gkbar_cagk=0.001 // gl_ichan2 = 0.000063 // cm=1.0 // insert pas // g_pas = 4e-05 // } forsec mdend {insert ichan2 gnatbar_ichan2=0.008 gkfbar_ichan2=0.001 gksbar_ichan2=0.006 insert nca // HAV-N- Ca channel gncabar_nca=0.001 // check to modify- original 0.004 insert lca glcabar_lca=0.0005 insert cat gcatbar_cat=0.0005 insert gskch gskbar_gskch=0.0 insert cagk gkbar_cagk=0.0024 gl_ichan2 = 0.000063 cm=1.0 insert pas g_pas = 4e-05} forsec ddend {insert ichan2 gnatbar_ichan2=0.008 gkfbar_ichan2=0.001 gksbar_ichan2=0.008 insert nca // HAV-N- Ca channel gncabar_nca=0.001 // check to modify- original 0.004 insert lca glcabar_lca=0.0 insert cat gcatbar_cat=0.001 insert gskch gskbar_gskch=0.0 insert cagk gkbar_cagk=0.0024 gl_ichan2 = 0.000063 cm=1.0 insert pas g_pas = 4e-05} // connect dend[0](0), soma(1) // connect gcdend2[0](0), soma(1) // for i=1,3 { // connect dend[i](0), dend[i-1](1) // } // for i=1,3 { // connect gcdend2[i](0), gcdend2[i-1](1) // } connect dend(0), soma(1) for i = 1, 2 connect dend[i](0), dend(1) for i = 3, 4 connect dend[i](0), dend[1](1) for i = 5, 6 connect dend[i](0), dend[2](1) for i = 7, 8 connect dend[i](0), dend[4](1) basic_shape() // connect axon(1), soma(0) forsec all {enat = 45 ekf = -90 eks = -90 ek=-90 elca=130 etca=130 esk=-90 el_ichan2 =-70 cao_ccanl=2 } // make catau slower70e-3 cao=2 cai=50.e-6 // current injection //for i=0,0 { //stimdel[i]=500 //stimdur[i]=200 //stimamp[i]=0.2 //soma stim[i] = new IClamp(0.5) //stim.del[i]=stimdel[i] //stim.dur[i]=stimdur[i] //stim.amp[i]=stimamp[i] //} } proc shape3d_1() { // axon {pt3dclear() // pt3dadd(-0.1761, -38, 0, 0.2) // pt3dadd(-0.1761, -18, 0, 10) // } // soma {pt3dclear() // pt3dadd(-0.121, -0.4145, 0.01, 10.45) pt3dadd(0.9829, -18, 0, 10) pt3dadd(0.9829, -1.102, 0, 11.34) } dend {pt3dclear() pt3dadd(0.9829, -1.102, 0, 11.34) pt3dadd(6.49, -6.16, 0, 2.88) pt3dadd(7.05, -7.81, 1, 2.69) pt3dadd(7.51, -9.19, 3.3, 1.86) pt3dadd(7.98, -10.66, 3.49, 1.39) pt3dadd(8.72, -12.04, 3.49, 1.39) pt3dadd(9.18, -13.33, 3.62, 1.86) pt3dadd(9, -14.71, 3.62, 2.13) pt3dadd(8.53, -16.18, 3.94, 1.67) pt3dadd(7.79, -17.74, 3.62, 1.39) pt3dadd(9, -19.03, 3.62, 1.3) pt3dadd(10.3, -20.41, 3.31, 1.21) pt3dadd(11.13, -21.51, 3.45, 1.48) pt3dadd(11.5, -22.8, 3.45, 1.48) pt3dadd(12.06, -24.69, 3.51, 1.39) pt3dadd(12.53, -26.72, 3.01, 1.21) pt3dadd(12.81, -28.92, 2.85, 1.21) pt3dadd(12.9, -30.58, 2.85, 1.11) pt3dadd(13.64, -31.96, 3.26, 1.11) pt3dadd(14.1, -33.79, 2.56, 1.11) pt3dadd(14.1, -35.54, 2.56, 1.21) pt3dadd(14.2, -37.01, 2.29, 1.67) } dend[1] {pt3dclear() pt3dadd(14.2, -37.01, 2.29, 1.67) pt3dadd(12.79, -37.7, 2, 1.11) pt3dadd(12.05, -38.62, 2.91, 0.74) pt3dadd(11.59, -40, 2.51, 0.83) pt3dadd(11.68, -41.47, 2.51, 0.65) pt3dadd(11.68, -43.21, 2.51, 1.02) pt3dadd(10.94, -44.41, 2.51, 1.02) pt3dadd(10.94, -45.51, 2.54, 0.74) pt3dadd(11.12, -46.8, 2.3, 0.65) pt3dadd(11.22, -47.9, 2.3, 1.11) pt3dadd(10.94, -49.65, 2.3, 1.11) pt3dadd(10.47, -51.12, 2.24, 1.11) pt3dadd(10.01, -52.22, 2.24, 0.93) pt3dadd(9.92, -53.42, 2.53, 0.74) pt3dadd(10.57, -54.43, 2.53, 0.74) pt3dadd(11.34, -55.26, 2.12, 0.74) pt3dadd(10.78, -57.01, 1.54, 0.93) pt3dadd(10.04, -58.57, 1.54, 1.21) pt3dadd(9.39, -59.68, 1.54, 0.93) pt3dadd(8.93, -60.87, 0.78, 0.74) pt3dadd(8.74, -62.25, 0.78, 1.02) pt3dadd(8.74, -63.81, 0.78, 1.21) pt3dadd(8.84, -65.19, 0.78, 1.11) pt3dadd(8.93, -66.48, 1.44, 0.93) pt3dadd(8.74, -67.95, 1.43, 1.11) pt3dadd(8.93, -69.33, 2.05, 1.02) pt3dadd(9.58, -70.8, 2.05, 1.02) pt3dadd(9.49, -71.72, 1.51, 0.93) pt3dadd(9.49, -72.73, 1.51, 0.74) pt3dadd(10.05, -73.66, 1.56, 0.74) pt3dadd(9.96, -74.67, 1.56, 0.65) pt3dadd(9.77, -75.77, 1.93, 1.11) pt3dadd(9.68, -76.51, 1.93, 1.11) pt3dadd(9.58, -77.61, 1.93, 0.65) pt3dadd(9.49, -78.9, 1.7, 0.65) pt3dadd(9.31, -80.18, 1.49, 0.65) pt3dadd(9.21, -81.75, 1.49, 0.83) pt3dadd(9.03, -82.94, 1.33, 0.74) pt3dadd(8.75, -84.23, 1.35, 0.74) pt3dadd(8.56, -85.7, 1.71, 0.74) pt3dadd(8.84, -86.8, 0.88, 0.83) pt3dadd(9.12, -88, 1.34, 1.02) pt3dadd(9.31, -89.19, 1.43, 0.93) pt3dadd(9.49, -90.57, 1.26, 0.93) pt3dadd(9.31, -91.73, 1.26, 0.93) pt3dadd(9.22, -93.29, 2.04, 1.02) pt3dadd(9.31, -94.4, 2.04, 1.39) pt3dadd(9.22, -95.96, 2.03, 1.11) pt3dadd(9.5, -97.06, 1.49, 0.93) pt3dadd(9.41, -98.63, 1.49, 0.93) pt3dadd(8.76, -99.64, 1.14, 0.93) pt3dadd(8.66, -101, 1.66, 0.74) pt3dadd(8.76, -102.4, 1.07, 1.3) } dend[2] {pt3dclear() pt3dadd(14.2, -37.01, 2.29, 1.67) pt3dadd(15.4, -38.21, 1.95, 1.21) pt3dadd(15.77, -39.59, 1.24, 0.93) pt3dadd(16.79, -40.5, 1.24, 0.74) pt3dadd(17.54, -41.33, 0.79, 0.93) pt3dadd(18.33, -42.36, 0.96, 0.74) pt3dadd(19.63, -43.37, 0.43, 0.74) pt3dadd(21.02, -44.38, 0.47, 0.74) pt3dadd(22.5, -45.58, 0.47, 0.74) pt3dadd(22.04, -46.86, 0.47, 0.83) pt3dadd(21.57, -48.43, 0.47, 1.02) pt3dadd(20.92, -49.71, 0.47, 0.83) pt3dadd(20, -50.63, 0.56, 1.21) pt3dadd(18.88, -51.28, 0.56, 0.83) pt3dadd(18.05, -52.84, 1.2, 0.74) pt3dadd(17.77, -54.22, 1.64, 1.02) pt3dadd(17.68, -55.5, 1.64, 1.21) pt3dadd(18.42, -56.7, 1.64, 0.93) pt3dadd(18.05, -57.89, 2.22, 0.74) pt3dadd(17.49, -59, 2.22, 0.74) pt3dadd(17.49, -60.01, 1.92, 0.93) pt3dadd(17.58, -61.79, 1.92, 1.21) pt3dadd(17.49, -63.36, 1.92, 0.83) pt3dadd(17.12, -65.1, 2.45, 0.74) pt3dadd(16.66, -66.48, 2.45, 1.02) pt3dadd(16.56, -68.14, 3.32, 0.74) pt3dadd(16.66, -70.25, 3.77, 0.93) pt3dadd(16.1, -71.45, 3.72, 1.02) pt3dadd(16.1, -72.82, 3.06, 0.65) pt3dadd(15.45, -73.93, 3.06, 0.65) pt3dadd(14.99, -74.94, 3.04, 0.74) pt3dadd(14.89, -76.78, 3.75, 0.93) pt3dadd(15.08, -78.43, 3.97, 0.93) pt3dadd(15.86, -80.09, 4.31, 0.74) pt3dadd(15.67, -81.65, 3.85, 0.83) pt3dadd(15.02, -83.03, 4.1, 0.74) pt3dadd(15.21, -84.68, 3.85, 0.93) pt3dadd(15.39, -86.34, 4.77, 0.93) pt3dadd(15.58, -88.08, 4.77, 1.11) pt3dadd(15.76, -89.19, 4.77, 0.93) pt3dadd(15.76, -91.02, 4.77, 0.74) pt3dadd(16.6, -92.95, 5.04, 0.74) pt3dadd(17.29, -94.63, 4.71, 0.83) pt3dadd(17.57, -96.2, 4.01, 1.67) } dend[3] {pt3dclear() pt3dadd(8.76, -102.4, 1.07, 1.3) pt3dadd(9.71, -102.9, 2.11, 0.65) pt3dadd(10.08, -104.1, 2.46, 0.65) pt3dadd(10.82, -104.8, 3.01, 0.65) pt3dadd(11, -106, 3.16, 0.46) pt3dadd(11.1, -108.1, 3.32, 0.46) pt3dadd(10.17, -108.4, 3.1, 0.46) pt3dadd(10.73, -110.5, 4.02, 0.46) pt3dadd(10.82, -111.7, 4.54, 0.46) pt3dadd(10.45, -113.7, 4.54, 0.83) pt3dadd(11.1, -114.8, 5.05, 0.65) pt3dadd(11.84, -115.4, 5.06, 0.46) pt3dadd(12.67, -117.4, 5.76, 0.46) pt3dadd(13.6, -118.9, 5.95, 0.46) pt3dadd(13.97, -120.8, 6.22, 0.46) pt3dadd(14.26, -122.8, 6.4, 0.65) pt3dadd(15.38, -124.4, 7.55, 0.56) pt3dadd(16.21, -125.5, 7.55, 0.56) pt3dadd(15.1, -127.8, 8.09, 0.56) pt3dadd(15.1, -129.3, 8.58, 0.56) pt3dadd(15.19, -130.2, 7.49, 1.02) pt3dadd(14.82, -131.2, 7.49, 1.02) pt3dadd(15.19, -132.1, 8.47, 0.65) pt3dadd(15.38, -133.3, 8.72, 0.46) pt3dadd(14.91, -134.7, 8.95, 0.46) pt3dadd(13.89, -135.7, 9.15, 0.46) pt3dadd(13.71, -137.6, 9.59, 0.46) pt3dadd(13.43, -139.4, 9.8, 0.46) pt3dadd(13.56, -141.1, 10.08, 0.46) pt3dadd(13.46, -142.5, 9.49, 0.46) } dend[4] {pt3dclear() pt3dadd(8.76, -102.4, 1.07, 1.3) pt3dadd(8.02, -103.6, 1.43, 0.65) pt3dadd(7.18, -104.8, 1.25, 0.56) pt3dadd(6.81, -105.4, 1.25, 0.65) pt3dadd(6.35, -106.8, 1.62, 0.56) pt3dadd(6.07, -107.9, 1.62, 0.56) pt3dadd(6.16, -109, 1.62, 0.56) pt3dadd(6.49, -110.1, 1.84, 0.56) pt3dadd(6.31, -111.5, 1.78, 0.56) pt3dadd(5.94, -112.8, 1.78, 0.74) pt3dadd(5.75, -113.9, 0.83, 0.65) pt3dadd(5.01, -115.2, 0.99, 0.65) pt3dadd(4.36, -116.1, 1.36, 0.65) pt3dadd(3.34, -115.7, 1.92, 0.56) pt3dadd(3.43, -117.5, 2.08, 0.56) pt3dadd(3.62, -118.9, 2.08, 0.65) } dend[5] {pt3dclear() pt3dadd(17.57, -96.2, 4.01, 1.67) pt3dadd(17.24, -97.63, 4.01, 1.58) pt3dadd(16.59, -99.01, 4.35, 0.74) pt3dadd(15.84, -101, 5.74, 0.56) pt3dadd(14.55, -102.3, 6.21, 0.56) pt3dadd(13.34, -103.3, 6.49, 0.56) pt3dadd(12.04, -105, 6.22, 0.56) pt3dadd(11.11, -106.5, 7, 0.56) pt3dadd(10.28, -108.7, 7.37, 0.56) pt3dadd(9.35, -110.1, 7.01, 0.56) pt3dadd(8.33, -111.5, 7.09, 0.56) pt3dadd(7.96, -113.1, 6.43, 0.56) pt3dadd(6.66, -114.9, 6.85, 0.56) pt3dadd(6.98, -117, 7.88, 0.56) pt3dadd(6.98, -119.5, 7.97, 0.56) pt3dadd(7.44, -122.1, 8.73, 0.56) pt3dadd(7.35, -124.9, 8.14, 0.56) pt3dadd(7.16, -126.6, 7.81, 0.56) pt3dadd(7.81, -128.4, 7.77, 0.56) pt3dadd(7.72, -130.1, 8.02, 0.56) } dend[6] {pt3dclear() pt3dadd(17.57, -96.2, 4.01, 1.67) pt3dadd(18.87, -97.21, 3.55, 1.11) pt3dadd(20.17, -98.95, 3.55, 0.65) pt3dadd(22.12, -100.8, 4.14, 0.65) pt3dadd(23.69, -102.3, 4.13, 0.65) pt3dadd(25.73, -103.6, 4.13, 0.65) pt3dadd(27.96, -105.4, 3.87, 0.56) pt3dadd(29.63, -107, 4.21, 0.56) pt3dadd(31.67, -108.5, 3.97, 0.56) pt3dadd(33.83, -110, 4.18, 0.56) pt3dadd(36.14, -111, 3.58, 0.56) pt3dadd(37.54, -111.2, 3.58, 0.56) pt3dadd(37.54, -113.1, 3.82, 0.74) } } proc shape3d_2() { dend[6] { pt3dadd(38.74, -114.5, 3.82, 0.74) pt3dadd(40.23, -116.5, 3.4, 0.56) pt3dadd(42.08, -118.6, 3.13, 0.56) pt3dadd(43.75, -120.6, 3.6, 0.56) pt3dadd(45.24, -122.2, 4.02, 0.56) pt3dadd(46.41, -123.4, 4.09, 0.56) pt3dadd(48.07, -124.6, 3.98, 0.56) pt3dadd(48.91, -125.6, 4.57, 0.56) pt3dadd(50.12, -126.8, 4.93, 0.56) pt3dadd(51.32, -128.2, 4.93, 0.56) pt3dadd(52.9, -129.7, 4.74, 0.56) pt3dadd(54.57, -131.8, 4.74, 0.46) pt3dadd(55.68, -133.4, 4.39, 0.46) pt3dadd(56.52, -134.8, 4.39, 0.46) } dend[7] {pt3dclear() pt3dadd(3.62, -118.9, 2.08, 0.65) pt3dadd(3.85, -120.4, 2.19, 0.37) pt3dadd(3.85, -121.8, 2.19, 0.56) pt3dadd(4.12, -123.3, 3.13, 0.65) pt3dadd(4.87, -124.4, 3.17, 0.56) pt3dadd(4.87, -126, 3.17, 0.56) } dend[8] {pt3dclear() pt3dadd(3.62, -118.9, 2.08, 0.65) pt3dadd(2.32, -119.9, 2.85, 0.28) pt3dadd(1.48, -120.9, 2.81, 0.28) pt3dadd(1.02, -122.5, 3.08, 0.28) pt3dadd(0.65, -123.7, 3.08, 0.28) pt3dadd(0.37, -125.3, 3.55, 0.28) pt3dadd(0.69, -126.7, 4.03, 0.37) pt3dadd(0.32, -129.4, 4.27, 0.37) pt3dadd(-0.24, -131.2, 4.65, 0.37) pt3dadd(-0.98, -132.9, 4.24, 0.37) pt3dadd(-1.16, -134.6, 3.96, 0.37) pt3dadd(-1.53, -136.1, 4.56, 0.37) pt3dadd(-2.09, -137.8, 4.56, 0.37) pt3dadd(-1.53, -139.6, 4.56, 0.37) pt3dadd(-0.42, -140.8, 4.78, 0.37) pt3dadd(0.97, -141.9, 4.78, 0.37) } } proc basic_shape() { shape3d_1() // shape3d_2() } proc connect_pre() { // $o1 target point process, $o2 returned NetCon soma $o2 = new NetCon (&v(1), $o1) //alternative statement $o1.soma pre_list.append(new NetCon(soma.v(1),syn,0,Delsyn,0)) } objref syn // objref DistalSynapses // objref DistalSynapsePositions objref ProximalSynapses objref ProximalSynapsePositions proc synapse() { // //***** PP syn // //***** MC syn ProximalSynapses = new Vector(0,0) ProximalSynapses .append(0, 1, 2) ProximalSynapsePositions = new Vector(0,0) ProximalSynapsePositions .append(0.5, 0.065185, 0.068277) for i= 0 , 2 { dend[ProximalSynapses .x[i]] syn = new Exp2Syn(ProximalSynapsePositions .x[i]) // // MC syn *** Estimated syn.tau1 = 1.5 syn.tau2 = 5.5 syn.e = 0 pre_list.append(syn) // # } // //***** HIPP // //***** BC syn soma syn = new Exp2Syn(0.5) // BC syn syn based on Bartos syn.tau1 = 0.26 syn.tau2 = 5.5 syn.e = -70 pre_list.append(syn) // # 0 // //***** Sprout for i= 0 , 2 { dend[ProximalSynapses .x[i]] syn = new Exp2Syn(ProximalSynapsePositions .x[i]) // // MC syn *** Estimated syn.tau1 = 1.5 syn.tau2 = 5.5 syn.e = 0 pre_list.append(syn) // # 0 } } func is_art() { return 0 } endtemplate GranuleCell5 //************************************************************************************************************