COMMENT
//%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
//
// NOTICE OF COPYRIGHT AND OWNERSHIP OF SOFTWARE
//
// Copyright 2007, The University Of Pennsylvania
// School of Engineering & Applied Science.
// All rights reserved.
// For research use only; commercial use prohibited.
// Distribution without permission of Maciej T. Lazarewicz not permitted.
// mlazarew@seas.upenn.edu
//
//%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
ENDCOMMENT
NEURON {
POINT_PROCESS Exp2SynAMPA
RANGE tau1, tau2, e, i
NONSPECIFIC_CURRENT i
RANGE S, total
GLOBAL c
}
UNITS {
(nA) = (nanoamp)
(mV) = (millivolt)
(uS) = (microsiemens)
}
PARAMETER {
tau1 = 1 (ms) <1e-9,1e9>
tau2 = 2 (ms) <1e-9,1e9>
e = 0 (mV)
c = 16.5
}
ASSIGNED {
v (mV)
i (nA)
S (uS)
factor (1)
total (1)
}
STATE {
A (uS)
B (uS)
}
INITIAL {
LOCAL tp
if (tau1/tau2 > .9999) {
tau1 = .9999*tau2
}
A = 0
B = 0
tp = (tau1*tau2)/(tau2 - tau1) * log(tau2/tau1)
factor = -exp(-tp/tau1) + exp(-tp/tau2)
factor = 1/factor
total = 0
}
BREAKPOINT {
SOLVE state METHOD cnexp
S = B - A
i = S * (v - e)
}
DERIVATIVE state {
A' = -A/tau1
B' = -B/tau2
}
NET_RECEIVE(w (uS) ) {
: the factor c comes from the fact that the synaptic mechanism described in the paper
: is using the presynaptic membrane potential continuously to define the differential equation
: and in NEURON these synapses are implemented by event based synapses
state_discontinuity(A, A + factor*c*w)
state_discontinuity(B, B + factor*c*w)
total = total + 1
}